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Chapter 5. Literature Evaluation II: Beyond the Basics
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Please select the best answer regarding which study design is presented.
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A crossover study to prospectively evaluate the use of an anticonvulsant drug for treatment of peripheral neuropathy in an individual patient.
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Please select the best answer regarding which study design is presented.
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A patient develops agranulocytosis after administration of dronedarone. The clinician writes and publishes this single patient observation.
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Please select the best answer regarding which study design is presented.
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An investigator evaluates the question of whether or not different digoxin products can be used interchangeably.
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Please select the best answer regarding which study design is presented.
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A company designs a trial to show that their new drug is therapeutically no worse than the standard of care therapy.
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When the 95% CI for a treatment difference between a test drug and reference drug crosses the NI margin, which of the following conclusions can be made?
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a. The test drug is noninferior to the reference drug.
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b. The reference drug is noninferior to the test drug.
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c. The results are inconclusive.
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d. The test drug is inferior to the reference drug.
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Adaptive clinical trial (ACT) design provides the ability to use:
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a. Emerging data to make adjustments in the study
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b. Flexible noninterim analysis strategies
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c. Adaptive sampling designs for reallocation of patients
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After reading the following three cases, identify the study design ...