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  • MTM providers should screen for medications that may contribute to urinary incontinence.

  • A combination of behavioral and drug therapies is the mainstay of treatment of urinary incontinence. Adherence to behavioral therapies should be assessed at each MTM encounter.

  • Medications for urinary incontinence are often difficult to tolerate because of anticholinergic effects; elderly patients may be particularly susceptible.

  • MTM providers should work with patients and prescribers to find the most acceptable regimen and help manage the adverse effects of medications for urinary incontinence.


The simple definition of urinary incontinence (UI) is involuntary loss of urine.1,2, and 3 The exact prevalence of UI is difficult to determine, but it is estimated by the expert panels who write consensus guidelines that 22% of American adults have some type of incontinence. UI is more common in women than in men, and data suggest that about one-quarter of young women, half of all postmenopausal women, and three-quarters of elderly women in nursing homes have some form of UI. Only 9% of men have some variation of UI.1, 2

The lower urinary tract includes the bladder, urethra, urinary sphincter, and surrounding connective tissue, nerves, as well as blood vessels. Under normal circumstances, the bladder detrusor muscle relaxes during filling and contracts during emptying. In contrast the urinary sphincter contracts during filling to prevent urine leakage and relaxes during emptying. These actions are mediated by the parasympathetic nervous system. Acetylcholine activity at muscarinic receptors throughout the urinary tract mediates urinary function. Usually, the bladder and sphincter work in unison. However, if anything disrupts this balance, then UI may occur (Table 28-1). Medications that influence the function of the lower urinary tract are presented in Table 28-2, and reversible causes of UI are outlined in Figure 28-1. There are several different types of UI, with urge incontinence being the most common.

Table 28-1.Differentiating Bladder Overactivity from Urethral Underactivity
Table 28-2.Medications that Influence Lower Urinary ...

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