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Harrison'sTM Principles of Internal Medicine, Nineteenth Edition Copyright © 2015 by McGraw-Hill Education. Previous editions copyright © 2012, 2008, 2005, 2001, 1998, 1994, 1991, 1987, 1983, 1980, 1977, 1974, 1970, 1966, 1962, 1958 by The McGraw-Hill Companies, Inc. All rights reserved. Printed in the United States of America. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a data base or retrieval system, without the prior written permission of the publisher.

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Two Volume Set ISBN 978-0-07-180215-4; MHID 0-07-180215-0

Volume 1 ISBN 978-0-07-180213-0; MHID 0-07-180213-4

Volume 2 ISBN 978-0-07-180214-7; MHID 0-07-180214-2

DVD ISBN 978-0-07-184876-3; MHID 0-07-184876-2

eBook ISBN 978-0-07-1802161; MHID 0-07-180216-9



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This book was set in Minion Pro by Cenveo® Publisher Services. The editors were James F. Shanahan and Kim J. Davis. The production manager was Jeffrey Herzich. Project management was provided by Tania Andrabi, Cenveo Publisher Services. The index was prepared by Susan Hunter. The text designer was Alan Barnett of alan barnett design; the cover design was by Anthony Landi.

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