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Chapter 28: Opportunistic Infections

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Pyrimethamine has been shown to cause bone marrow suppression. Which agent can be given in conjunction with pyrimethamine to lessen the suppressive effects?

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a. Vitamin B12

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b. Levofloxacin

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c. Dapsone

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d. Leucovorin

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Answer d is correct. Leucovorin has similar functionality when used with methotrexate.

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Answer a is incorrect. Folic Vitamin B12 will not have an effect on the bone marrow suppression of pyrimethamine.

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Answer b is incorrect. Levofloxacin, a fluoroquinolone, has not been shown to decrease bone marrow suppression.

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Answer c is incorrect. Dapsone prevents bacterial folic acid synthesis but has not been demonstrated to be helpful in bone marrow suppression.

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What is the brand name for moxifloxacin?

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a. Avelox

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b. Septra

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c. Mepron

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d. Aczone

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Answer a is correct. Avelox is the brand name of moxifloxacin.

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Answer b is incorrect. Septra is the brand name of sulfamethoxazole and trimethoprim.

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Answer c is incorrect. Mepron is the brand name of atovaquone.

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Answer d is incorrect. Aczone is the brand name of dapsone.

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JK is a patient at a local clinic with a recent diagnosis of AIDS. His past medical history includes hypertension, dyslipidemia, and depression. Medications include losartan, atorvastatin, and escitalopram. Labs include: CD4 count of 120 cells/mm3, serum and potassium 4.8 mEq/L (increased from 3.5 mEq/L). Which agent is recommended as a preferred therapy for PCP prophylaxis?

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a. Clindamycin

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b. TMP – SMX

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c. Amikacin

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d. Levofloxacin

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Answer b is correct. TMP–SMX is the preferred therapy for PCP prophylaxis despite its potassium retaining capabilities.

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Answer a is incorrect. Clindamycin, a lincosamide, is an alternative therapy for PCP prophylaxis.

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Answer c is incorrect. Amikacin, an aminoglycoside, is not preferred therapy for PCP prophylaxis.

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Answer d is incorrect. Levofloxacin, a fluoroquinolone, is not considered preferred therapy for PCP prophylaxis.

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LZ is a 52-year-old patient admitted to the hospital with complications of AIDS. The nurse informs the pharmacy resident that he is being treated for a PJP infection. She is unclear of the duration of therapy and asks the pharmacy ...

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