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Chapter 7. Toxicokinetics
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Regarding the two-compartment model of classic toxicokinetics, which of the following is true?
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a. There is rapid equilibration of chemical between central and peripheral compartments.
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b. The logarithm of plasma concentration versus time data yields a linear relationship.
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c. There is more than one dispositional phase.
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d. It is assumed that the concentration of a chemical is the same throughout the body.
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e. It is ineffective in determining effective doses in toxicity studies.
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When calculating the fraction of a dose remaining in the body over time, which of the following factors need not be taken into consideration?
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b. initial concentration.
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d. present concentration.
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e. elimination rate constant.
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All of the following statements regarding apparent volume of distribution (Vd) are true EXCEPT:
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a. Vd relates the total amount of chemical in the body to the concentration of chemical in the plasma.
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b. Vd is the apparent space into which an amount of chemical is distributed in the body to result in a given plasma concentration.
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c. A chemical that usually remains in the plasma has a low Vd.
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d. Vd will be low for a chemical with high affinity for tissues.
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e. Vd can be used to estimate the amount of chemical in the body if the plasma concentration is known.
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b. is unaffected by kidney failure.
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c. is indirectly proportional to Vd.
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d. is performed by multiple organs.
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e. is not appreciable in the GI tract.
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A chemical with which of the following half-lives (T1/2) will remain in the body for the longest period of time when given equal dosage of each?
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