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Chapter 13. Toxic Responses of the Liver

The impairment of hepatic function can have numerous negative consequences. Which of the following is likely NOT caused by impaired hepatic function?

a. jaundice.

b. hypercholesterolemia.

c. hyperammonemia.

d. hyperglycemia.

e. hypoalbuminemia.

All of the following statements regarding the liver are true EXCEPT:

a. The major role of the liver is to maintain metabolic homeostasis of the body.

b. The liver encounters ingested nutrients before the heart does.

c. Hepatic triads contain a branch of the hepatic portal vein, a branch of the hepatic artery, and a bile ductule.

d. The liver manufactures and stores bile.

e. The large fenestrae of hepatic sinusoids facilitate exchange of materials between the sinusoid and the hepatocyte.

Activation of which of the following cell types can result in increased secretion of collagen scar tissue, leading to cirrhosis?

a. hepatocyte.

b. Ito cell.

c. Kupffer cell.

d. endothelial cell.

e. β-cell.

Wilson’s disease is a rare genetic disorder characterized by the failure to export which of the following metals into bile?

a. iron.

b. zinc.

c. silver.

d. lead.

e. copper.

Which of the following is NOT characteristic of apoptosis?

a. cell swelling.

b. nuclear fragmentation.

c. lack of inflammation.

d. programmed death.

e. chromatin condensation.

A patient suffering from canalicular cholestasis would NOT be expected to exhibit which of the following?

a. increased bile salt serum levels.

b. jaundice.

c. increased bile formation.

d. dark brown urine.

e. vitamin A deficiency.

Which of the following statements regarding liver injury is FALSE?

a. Large doses of acetaminophen have been shown to cause ...

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