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Chapter 19. Toxic Responses of the Skin

Which of the following statements is FALSE regarding skin histology?

a. Blood supply to the epidermis originates in the epidermal–dermal junction.

b. Melanin is made and stored by melanocytes.

c. The stratum corneum is made up of nonviable cells.

d. It takes approximately 2 weeks for cells to be sloughed off from the stratum corneum.

e. Stem cells in the basal layer replenish the keratinocytes of the layers of epidermis.

Transdermal drug delivery does NOT:

a. prevent drug exposure to low pH.

b. avoid first-pass metabolism.

c. provide steady infusion over an extended period of time.

d. avoid large variation in drug plasma concentration.

e. increase safety of drug delivery.

Irritant and contact dermatitis are marked by all of the following characteristics EXCEPT:

a. softness.

b. erythema.

c. flaking.

d. induration.

e. blistering.

Nickel is a common cause of allergic contact dermatitis, which is which type of hypersensitivity reaction?

a. type I.

b. type II.

c. type III.

d. type IV.

e. type V.

All of the following statements regarding phototoxicology are true EXCEPT:

a. Melanin is primarily responsible for the absorption of UV-B radiation.

b. UV-A is the most effective at causing sunburn in humans.

c. IL-1 release is responsible for systemic symptoms associated with sunburn.

d. Melanin darkening is a common response to UV exposure.

e. UV radiation exposure causes thickening of the stratum corneum.

Photoallergies:

a. represent a form of type III hypersensitivity reaction.

b. can occur without exposure to UV radiation.

c. are hapten-mediated

d. cannot be tested for as contact dermatitis allergies can.

e. often occur on first exposure.

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