| 1A2 | Acetaminophen, antipyrine, caffeine, clomipramine, duloxetine, melatonin, phenacetin, ramelteon, tacrine, tamoxifen, theophylline, warfarin | Smoking, charcoal-broiled foods, cruciferous vegetables, lansoprazole, omeprazole | Galangin, furafylline, fluvoxamine |
| 2A6 | Coumarin, tobacco nitrosamines, nicotine (to cotinine and 2′--hydroxynicotine) | Efavirenz, rifampin, phenobarbital | Tranylcypromine, menthofuran, methoxsalen |
| 2B6 | Artemisinin, bupropion, clopidogrel, cyclophosphamide, efavirenz, ifosfamide, ketamine, S-mephobarbital, S-mephenytoin (N-demethylation to nirvanol), methadone, nevirapine, propofol, selegiline, sertraline, ticlopidine | Phenobarbital, cyclophosphamide | Clopidogrel, paroxetine, phencyclidine, sertraline, thiotepa, ticlopidine |
| 2C8 | Taxol, all-trans-retinoic acid | Rifampin, barbiturates | Gemfibrozil, montelukast, trimethoprim, quercetin, rosiglitazone, pioglitazone |
| 2C9 | Celecoxib, diclofenac, flurbiprofen, hexobarbital, ibuprofen, losartan, phenytoin, tolbutamide, trimethadione, sulfaphenazole, S-warfarin, ticrynafen | Barbiturates, carbamazepine, rifampin | Fluconazole, fluvoxamine, sulfaphenazole, tienilic acid |
| 2C18 | Tolbutamide, phenytoin | Phenobarbital | |
| 2C19 | Diazepam, S-mephenytoin, naproxen, nirvanol, omeprazole, propranolol | Barbiturates, rifampin | N3-benzylnirvanol, N3-benzylphenobarbital, fluconazole, nootkatone, ticlopidine |
| 2D6 | Atomoxetine, bufuralol, bupranolol, clomipramine, clozapine, codeine, debrisoquine, desipramine, dextromethorphan, encainide, flecainide, fluoxetine, guanoxan, haloperidol, hydrocodone, 4 --methoxy-amphetamine, metoprolol, mexiletine, nebivolol, oxycodone, perphenazine, paroxetine, phenformin, propafenone, propoxyphene, risperidone, selegiline (deprenyl), sparteine, tamoxifen, tolterodine, thioridazine, timolol, tricyclic antidepressants, venlafaxine | Unknown | Bupropion, fluoxetine, paroxetine, quinidine |
| 2E1 | Acetaminophen, chlorzoxazone, enflurane, halothane, ethanol (a minor pathway) | Ethanol, isoniazid | Clomethiazole, disulfiram, diethyldithiocarbamate, diallyl sulfide, 4 --methylpyrazole |
| 3A41 | Acetaminophen, alfentanil, amiodarone, aprepitant, astemizole, buspirone, cisapride, cocaine, conivaptan, cortisol, cyclosporine, dapsone, darunavir, dasatinib, diazepam, dihydroergotamine, dihydropyridines, diltiazem, erythromycin, ethinyl estradiol, everolimus, felodipine, fluticasone, gestodene, indinavir, lidocaine, lopinavir, lovastatin, macrolides, maraviroc, methadone, miconazole, midazolam, mifepristone, nifedipine, nisoldipine, paclitaxel progesterone, quetiapine, quinidine, rapamycin, ritonavir, saquinavir, sildenafil, simvastatin, sirolimus, spironolactone, sulfamethoxazole, sufentanil, tacrolimus, tamoxifen, terfenadine, testosterone, tetrahydrocannabinol, tolvaptan, tipranavir, triazolam, troleandomycin, vardenafil, verapamil | Avasimibe, barbiturates, carbamazepine, glucocorticoids, pioglitazone, phenytoin, rifampin, St. John's wort | Amprenavir, azamulin, boceprevir, clarithromycin, conivaptan, diltiazem, erythromycin, fluconazole, grapefruit juice (furanocoumarins), indinavir, itraconazole, ketoconazole, lopinavir, mibefradil, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, telithromycin, troleandomycin, verapamil, voriconazole |