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Chapter 34: Poxviruses

A patient presents to the emergency room with vesicular lesions on both hands potentially resembling smallpox. A public health investigation is begun to rule out smallpox. The patient is an immigrant working as a shepherd in several states. What is the most likely cause of his skin lesions?

(A) Vaccinia virus

(B) Variola virus

(C) Monkeypox virus

(D) Tanapox virus

(E) Orf virus

An emergency services worker is considering smallpox ­vaccination because of the potential for bioterrorism. Which one of the following conditions is not a contraindication for the use of vaccinia (smallpox) vaccine under routine nonemergency conditions?

(A) Immunosuppression

(B) Severe allergy to a component of the vaccine

(C) Household contact with a person with eczema

(D) Pregnancy

(E) Previous smallpox vaccination

Which of the following poxviruses infects only humans?

(A) Monkeypox

(B) Molluscum contagiosum

(C) Tanapox

(D) Cowpox

(E) Yaba tumor virus

A 7-year-old boy has pox-like lesions on his left hand and arm. He has a pet rodent imported from West Africa. Monkeypox is diagnosed in the boy and the rodent. Which of the following statements about monkeypox virus is most correct?

(A) Clinical disease resembles smallpox.

(B) Human infections are never fatal.

(C) Smallpox vaccination is not protective.

(D) Infections are readily transmitted among family members.

(E) Virus particles can be distinguished from smallpox virus by electron microscopy.

Which of the following best describes the currently licensed smallpox vaccines?

(A) Live attenuated smallpox virus

(B) Inactivated smallpox virus

(C) Live vaccinia virus

(D) Inactivated vaccinia virus

(E) Reassortant vaccine containing both vaccinia and smallpox viruses

Which of the following does not apply to vaccinia virus replication in cultured cells?


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