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Applied Biopharmaceutics & Pharmacokinetics, Seventh Edition Copyright © 2016 by McGraw-Hill Education. All rights reserved. Printed in the United States of America. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a data base or retrieval system, without the prior written permission of the publisher.

Previous editions copyright © 2012 by The McGraw-Hill Companies, Inc.; © 2005, 1999, 1993 by Appleton & Lange; © 1985, 1980 by Appleton-Century-Crofts.

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ISBN 978-0-07-183093-5

MHID 0-07-183093-6

This book was set in Times LT Std by Cenveo® Publisher Services.

The editor were Michael Weitz and Regina Y. Brown.

The production supervisor was Rick Ruzycka.

The production manager was Tanya Punj, Cenveo Publisher Services.

The design was by Elise Lansdon; the cover design was by Barsoom Design, with cover art © Gregor Schuster/Corbis.

RR Donnelley was printer and binder.

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