1A, B, C | Preexponential constants for three-compartment model equation |
a, b, c | Exponents for three-compartment model equation |
α | Probability of making a type 1 error |
β | Probability of making a type 2 error |
α, β, γ | Exponents for three-compartment model equation (equivalent to a, b, c above) |
λ1, λ2, λ3 | Exponents for three-compartment-type exponential equation (equivalent to a, b, c above; more terms may be added and indexed numerically with λ subscripts for multiexponential models) |
Delta (Δ) | Delta is sometimes referred to as the “effect size” and is a measure of the degree of difference between tested population samples |
μ0 | The null hypothesis value for the mean |
μa | μa is the alternative hypothesis value expected for the mean |
ϰ2 | Chi-square test |
A or Ab | Amount of drug in the body of time t; see also DB |
Ab∞ | Total amount of drug in the body |
ABC | ABC transport protein |
ABW | Average body weight |
AE | Adverse event |
ANCOVA | Analyses of covariance |
ANDA | Abbreviated New Drug Application; see also NDA |
ANOVA | Analysis of variance |
API | Active pharmaceutical ingredient |
AR | Absolute risk |
ARI | Absolute risk increase |
AUC | Area under the plasma level–time curve |
[AUC]∞0 | Area under the plasma level–time curve extrapolated to infinite time |
[AUC]t0 | Area under the plasma level–time curve from t = 0 to last measurable plasma drug concentration at time t |
AUMC | Area under the (first) moment–time curve |
BA | Bioavailability |
BCS | Biopharmaceutics Classification System |
BDDCS | Drug disposition classification system |
BE | Bioequivalence |
BioRAM | Biopharmaceutics Risk Assessment Roadmap |
BLA | Biologic license application |
BM | Biomarker |
BMI | Body mass index |
BRCP | Breast cancer-resistance protein (an ABC transporter) |
BUN | Blood urea nitrogen |
C | Concentration (mass/volume) |
Ca | Drug concentration in arterial plasma |
C∞av | Average steady-state plasma drug concentration |
Cc or Cp | Concentration of drug in the central compartment or in plasma |
Ccr | Serum creatinine concentration, usually expressed as mg% |
CE | Clinical endpoint |
Ceff | Minimum effective drug concentration |
CGI | Concentration of drug in gastrointestinal tract |
CI | Confidence interval |
Cm | Metabolite plasma concentration |
Cmax | Maximum concentration of drug |
C∞max | Maximum steady-state drug concentration; see also Cssmax |
Cmin | Minimum concentration of drug |
C∞max | Minimum steady-state drug concentration; see also Cssmin |
Cp | Concentration of drug in plasma |
C0p | Concentration of drug in plasma at zero time (t = 0) (equivalent to C0) |
C∞p | Steady-state plasma drug concentration (equivalent to Css) |
Cpn | Last measured plasma drug concentration |
Css | Concentration of drug at steady state |
Cssav | Average concentration at steady state |
Cssmax | Maximum concentration at steady state |
Cssmin | Minimum concentration at steady state |
Ct | Concentration of drug in tissue |
cGMP | Current Good ... |