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This Workbook and Casebook derives from the 12th edition of Goodman & Gilman’s The Pharmacological Basis of Therapeutics. The organization of the parent text has been retained and many of the tables and figures are the same. The editors have attempted to provide the most important concepts from the 12th edition of G&G in a user-friendly format without the elimination of salient pharmacological information. It is our intention that the Workbook and Casebook will complement the parent text and the second edition of Goodman & Gilman’s Manual of Pharmacology and Therapeutics and be useful to students and educators who might need a companion text in an advanced pharmacology course.

The number of chapters in the Workbook and Casebook has been reduced from 67 to 48 by combining the substance of multiple chapters from the 12th edition into one Workbook and Casebook chapter. For example, Chapter 9 Muscarinic Receptor Agonists and Antagonists, Chapter 10 Anticholinesterase Agents, and Chapter 11 Agents Acting at the Neuromuscular Junction and Autonomic Ganglia in the 12th edition have been combined into one Workbook chapter entitled Cholinergic Pharmacology. An additional chapter, Chapter 4 Special Populations: Children and the Elderly, has been added to the Workbook and Casebook based in part on content that is published in Updates in the online version of Goodman & Gilman ( and

Each Workbook and Casebook chapter begins with a statement of how it differs from the 12th edition so that the reader can refer to the parent text to obtain additional information if necessary. Workbook and Casebook chapters (except for chapters on general principles) are formatted as follows:

  • Learning Objectives

  • Drugs Included in the Chapter

  • Mechanisms of Action (and, where appropriate, Mechanisms of Resistance) Table

  • Clinical Cases

  • Key Concepts

  • Summary Quiz

  • Summary Table of Drugs that includes Drug Class, Drug Name, Clinical Uses, and Common and Unique Clinically Important Toxicities

Additional Side Bars are included to highlight significant pharmacological information. Narrative pharmacological information is provided in the form of Clinical Cases to give a clinical context for the therapeutic use of drugs and their adverse events. We have omitted research data, chemical structures, references, and the pharmacokinetic data of Appendix II, all of which can be found on the G&G Web site on and, along with pharmacotherapeutic updates and mechanistic animations.

We thank the contributors and editors of the 12th edition of G&G, Christie Naglieri and James Shanahan of McGraw Hill, and the long line of contributors and editors who have worked on Goodman & Gilman over 12 editions. It is an honor to follow in the path of Louis Goodman and Alfred Gilman, and it is a tribute to their writing and editing that their book is useful and relevant 74 years after the publication of the first edition.

Douglas E. Rollins
Donald K. Blumenthal

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