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This chapter will be most useful after having a basic understanding of the material related to angina at the beginning of Chapter 27, Treatment of Myocardial Ischemia and Hypertension in Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12th Edition. In addition to the material presented here, the 12th Edition contains:
Table 27-1 Organic Nitrates Available for Clinical Use, which provides information about the preparations, usual doses, and routes of administration of organic nitrates
The molecular structures of drugs used to treat myocardial ischemia
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Understand the mechanisms of action of drugs used to treat myocardial ischemia and relieve symptoms of angina.
Understand the goals of treatment based on a knowledge of the underlying cause(s) of angina.
Know which drugs are most effective in treating different types of angina.
Know which drugs are used in combination to treat angina.
Know the untoward effects and contraindications of the major classes of drugs used to treat angina.
Know the role of drug-eluting stents to treat patients with acute coronary syndromes.
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DRUGS INCLUDED IN THIS CHAPTER
Antithrombin agents (see Chapter 19)
Antiplatelet drugs (see Chapter 19)
β Adrenergic receptor antagonists (see Chapter 7)
Numerous dihydropyridines (nifedipine [ADALAT, PROCARDIA, others], amlodipine [NORVASC, others], felodipine [PLENDIL, others], isradipine [DYNACIRC, others], nicardipine [CARDENE, others], nisoldipine, nimodipine, clevidipine, others)
Diltiazem (CARDIZEM, DILACOR-XR, others)
Isosorbide dinitrate (ISDN; ISORDIL, SORBITRATE, DILATRATE-SR, others)
Isosorbide-5-mononitrate (ISMN; IMDUR, ISMO, others)
Nitroglycerin (glyceryl trinitrate; NITRO-BID, NITROSTAT, NITROL, NITRO-DUR, others)
Paclitaxel drug-eluting stents
Ranolazine (RANEXA)
Sildenafil (VIAGRA, REVATIO)
Sirolimus drug-eluting stents
Tadalafil (CIALIS, ADCIRCA)
Thrombolytic agents (see Chapter 19)
Vardenafil (LEVITRA)
Verapamil (CALAN, ISOPTIN, others)
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