Skip to Main Content

++

INTRODUCTION

++

This chapter will be most useful after having a basic understanding of the material related to angina at the beginning of Chapter 27, Treatment of Myocardial Ischemia and Hypertension in Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12th Edition. In addition to the material presented here, the 12th Edition contains:

  • Table 27-1 Organic Nitrates Available for Clinical Use, which provides information about the preparations, usual doses, and routes of administration of organic nitrates

  • The molecular structures of drugs used to treat myocardial ischemia

++

LEARNING OBJECTIVES

++

  • Understand the mechanisms of action of drugs used to treat myocardial ischemia and relieve symptoms of angina.

  • Understand the goals of treatment based on a knowledge of the underlying cause(s) of angina.

  • Know which drugs are most effective in treating different types of angina.

  • Know which drugs are used in combination to treat angina.

  • Know the untoward effects and contraindications of the major classes of drugs used to treat angina.

  • Know the role of drug-eluting stents to treat patients with acute coronary syndromes.

++

DRUGS INCLUDED IN THIS CHAPTER

  • Antithrombin agents (see Chapter 19)

  • Antiplatelet drugs (see Chapter 19)

  • β Adrenergic receptor antagonists (see Chapter 7)

  • Numerous dihydropyridines (nifedipine [ADALAT, PROCARDIA, others], amlodipine [NORVASC, others], felodipine [PLENDIL, others], isradipine [DYNACIRC, others], nicardipine [CARDENE, others], nisoldipine, nimodipine, clevidipine, others)

  • Diltiazem (CARDIZEM, DILACOR-XR, others)

  • Isosorbide dinitrate (ISDN; ISORDIL, SORBITRATE, DILATRATE-SR, others)

  • Isosorbide-5-mononitrate (ISMN; IMDUR, ISMO, others)

  • Nitroglycerin (glyceryl trinitrate; NITRO-BID, NITROSTAT, NITROL, NITRO-DUR, others)

  • Paclitaxel drug-eluting stents

  • Ranolazine (RANEXA)

  • Sildenafil (VIAGRA, REVATIO)

  • Sirolimus drug-eluting stents

  • Tadalafil (CIALIS, ADCIRCA)

  • Thrombolytic agents (see Chapter 19)

  • Vardenafil (LEVITRA)

  • Verapamil (CALAN, ISOPTIN, others)

++
Table Graphic Jump Location
MECHANISMS OF ACTION OF DRUGS USED TO TREAT MYOCARDIAL ISCHEMIA

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.