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INTRODUCTION

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This chapter will be most useful after having a basic understanding of the material in Chapter 28, Pharmacotherapy of Heart Failure in Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12th Edition. In particular, the reader is directed to the following table:

  • Table 28-3, Vasodilator Drugs Used to Treat Heart Failure, which shows drugs used as vasodilators to treat heart failure including their mechanism of action and their effects on preload and afterload

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LEARNING OBJECTIVES

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  • Know the stages of heart failure and the treatments that are recommended at each stage.

  • Understand the rationale for the use of drugs that prevent and slow the progression of heart failure.

  • Understand the mechanism of action of inotropic drugs and how they are used to maintain left ventricular function.

  • Identify the major side effects and adverse drug reactions of the drugs used to treat heart failure.

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DRUGS IN THIS CHAPTER

  • Bisoprolol (ZEBETA)

  • Candesartan (ATACAND)

  • Captopril (CAPOTEN, others)

  • Carvedilol (COREG, others)

  • Digoxin (LANOXIN, others)

  • Dobutamine (DOBUTREX, others)

  • Dopamine

  • Enalapril (VASOTEC, others)

  • Eplerenone (INSPRA, others)

  • Furosemide (LASIX, others)

  • Hydralazine (APRESOLINE)

  • Hydralazine and isosorbide dinitrate (BIDIL)

  • Inamrinone (INOCOR)

  • Isosorbide dinitrate (ISORDIL, SORBITRATE, others)

  • Labetalol (NORMODYNE, TRANDATE, others)

  • Lisinopril (PRINIVIL, ZESTRIL, others)

  • Losartan (COZAAR)

  • Metoprolol (LOPRESSOR, TOPROL XL, others)

  • Milrinone (PRIMACOR IV)

  • Minoxidil (LONITEN)

  • Nesiritide (NATRECOR)

  • Nitroglycerin (trinitroglycerin, NITROSTAT, NITRO-BID, others)

  • Nitroprusside (NITROPRESS, others)

  • Spironolactone (ALDACTONE)

  • Thiazide diuretics (many, see Chapter 15)

  • Valsartan (DIOVAN)

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Table Graphic Jump Location
MECHANISMS OF ACTIONS OF DRUGS USED TO TREAT HEART FAILURE (SEE FIGURE 17-1)

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