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This chapter will be most useful after having a basic understanding of the material in Chapter 33, Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor, and Chapter 34, Anti-inflammatory, Antipyretic, and Analgesic Agents: Pharmacotherapy of Gout in Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12th Edition. In addition to the material presented here, the 12th Edition contains:
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Table 33-1 Eicosanoid Receptors that lists the major classes of eicosanoid receptors and their signaling characteristics
The molecular structures of lipid-derived autacoids, nonsteroidal anti-inflammatory drugs (NSAIDs), and drugs used to treat gout
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Understand the mechanisms of action of drugs used as prostaglandin agonists.
Understand the mechanisms of action of the NSAIDs.
Understand the mechanisms of action of the drugs used in the pharmacotherapy of gout.
Know the untoward effects of prostaglandin agonists, NSAIDs, and the drugs used in the pharmacotherapy of gout.
Know the therapeutic utility of prostaglandin agonists, NSAIDs, and the drugs used in the pharmacotherapy of gout.
Know which drugs can be used in combination, and those that should not be used concomitantly to treat inflammatory disorders, fever, pain, arthritis, and gout.
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DRUGS INCLUDED IN THIS CHAPTER
Acetaminophen (TYLENOL, others)
Allopurinol (ZYLOPRIM, ALOPRIM, others)
Alprostadil (CAVERJECT, EDEX, MUSE, PROSTIN VR PEDIATRIC)
Aspirin (acetylsalicylic acid, ASA)
Balsalazide (COLAZOL, others)
Bimatoprost (LUMIGAN)
Bromfenac (XIBROM)
Carboprost tromethamine (HEMABATE)
Celecoxib (CELEBREX)
Colchicine
Diclofenac (CATAFLAM, ZIPSOR, FLECTOR, VOLTAREN, SOLAREZE, CAMBIA, others)
Diflunisal
Dinoprostone (CERVIDIL, PREPIDIL)
Etodolac (LODINE)
Febuxostat (ULORIC)
Fenoprofen (NALFON 200, others)
Flurbiprofen (ANSAID, OCUFEN, others)
Ibuprofen (ADVIL, MOTRIN, NEOPROFEN, CALDOLOR, others)
Iloprost (VENTAVIS)
Indomethacin (INDOCIN, others)
Ketoprofen
Ketorolac (ACULAR, others)
Latanoprost (XALATAN)
Meclofenamate (MECLOMEN)
Mefenamic acid (PONSTEL)
Meloxicam (MOBIC, others)
Mesalamine (ASACOL, LIALDA, APRISO, DIPENTUM, CANASA)
Misoprostol (CYTOTEC)
Nabumetone (RELAFEN)
Naproxen (ALEVE, NAPROSYN, others)
Nepafenac (NEVANAC)
Olsalazine
Oxaprozin (DAYPRO)
Piroxicam (FELDENE, others)
Probenecid (PROBALAN)
Prostacyclin (epoprostenol, FLOLAN)
Rasburicase (ELITEK)
Salicylate (DOAN’S, MOMENTUM, others)
Salsalate
Sulfasalazine (AZULFIDINE, others)
Sulindac (CLINORIL, others)
Tolmetin (TOLECTIN, others)
Travoprost (TRAVATAN)
Treprostinil (REMODULIN)
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