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INTRODUCTION

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This chapter will be most useful after having a basic understanding of the material in Chapter 33, Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor, and Chapter 34, Anti-inflammatory, Antipyretic, and Analgesic Agents: Pharmacotherapy of Gout in Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12th Edition. In addition to the material presented here, the 12th Edition contains:

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  • Table 33-1 Eicosanoid Receptors that lists the major classes of eicosanoid receptors and their signaling characteristics

  • The molecular structures of lipid-derived autacoids, nonsteroidal anti-inflammatory drugs (NSAIDs), and drugs used to treat gout

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LEARNING OBJECTIVES

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  • Understand the mechanisms of action of drugs used as prostaglandin agonists.

  • Understand the mechanisms of action of the NSAIDs.

  • Understand the mechanisms of action of the drugs used in the pharmacotherapy of gout.

  • Know the untoward effects of prostaglandin agonists, NSAIDs, and the drugs used in the pharmacotherapy of gout.

  • Know the therapeutic utility of prostaglandin agonists, NSAIDs, and the drugs used in the pharmacotherapy of gout.

  • Know which drugs can be used in combination, and those that should not be used concomitantly to treat inflammatory disorders, fever, pain, arthritis, and gout.

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DRUGS INCLUDED IN THIS CHAPTER

  • Acetaminophen (TYLENOL, others)

  • Allopurinol (ZYLOPRIM, ALOPRIM, others)

  • Alprostadil (CAVERJECT, EDEX, MUSE, PROSTIN VR PEDIATRIC)

  • Aspirin (acetylsalicylic acid, ASA)

  • Balsalazide (COLAZOL, others)

  • Bimatoprost (LUMIGAN)

  • Bromfenac (XIBROM)

  • Carboprost tromethamine (HEMABATE)

  • Celecoxib (CELEBREX)

  • Colchicine

  • Diclofenac (CATAFLAM, ZIPSOR, FLECTOR, VOLTAREN, SOLAREZE, CAMBIA, others)

  • Diflunisal

  • Dinoprostone (CERVIDIL, PREPIDIL)

  • Etodolac (LODINE)

  • Febuxostat (ULORIC)

  • Fenoprofen (NALFON 200, others)

  • Flurbiprofen (ANSAID, OCUFEN, others)

  • Ibuprofen (ADVIL, MOTRIN, NEOPROFEN, CALDOLOR, others)

  • Iloprost (VENTAVIS)

  • Indomethacin (INDOCIN, others)

  • Ketoprofen

  • Ketorolac (ACULAR, others)

  • Latanoprost (XALATAN)

  • Meclofenamate (MECLOMEN)

  • Mefenamic acid (PONSTEL)

  • Meloxicam (MOBIC, others)

  • Mesalamine (ASACOL, LIALDA, APRISO, DIPENTUM, CANASA)

  • Misoprostol (CYTOTEC)

  • Nabumetone (RELAFEN)

  • Naproxen (ALEVE, NAPROSYN, others)

  • Nepafenac (NEVANAC)

  • Olsalazine

  • Oxaprozin (DAYPRO)

  • Piroxicam (FELDENE, others)

  • Probenecid (PROBALAN)

  • Prostacyclin (epoprostenol, FLOLAN)

  • Rasburicase (ELITEK)

  • Salicylate (DOAN’S, MOMENTUM, others)

  • Salsalate

  • Sulfasalazine (AZULFIDINE, others)

  • Sulindac (CLINORIL, others)

  • Tolmetin (TOLECTIN, others)

  • Travoprost (TRAVATAN)

  • Treprostinil (REMODULIN)

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Table Graphic Jump Location
MECHANISMS OF ACTION OF PROSTAGLANDINS AND THEIR ANALOGS

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