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INTRODUCTION

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This chapter will be most useful after having a basic understanding of the material in Chapter 38, Introduction to Endocrinology: The Hypothalamic Pituitary Axis in Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12th Edition. In addition to the material presented here, the 12th Edition includes:

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  • A detailed discussion of the hypothalamic-pituitary-endocrine axis

  • A description of the pituitary hormones and their releasing factors

  • A discussion of the therapy of growth hormone (GH) deficiency

  • A discussion of the glycoprotein hormones: thyroid stimulating hormone (TSH) and gonadotropins

  • A discussion of the posterior pituitary hormones: oxytocin and vasopressin

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LEARNING OBJECTIVES

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  • Understand the functioning of the hypothalamic-pituitary axis.

  • Describe the pharmacotherapy of GH excess and GH deficiency.

  • Develop knowledge of the clinical uses of gonadotropin-releasing hormone (GnRH) and its analogs.

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DRUGS INCLUDED IN THIS CHAPTER

Bromocriptine (PARLODEL, CYLOSERT, others)

Cabergoline (CABERLIN, DOSTINEX, CABASER)

Cetrorelix (CETROTIDE)

Choriogonadotropin alfa (OVIDREL)

Follitropin α (GONAL-F)

Follitropin β (FOLLISTIM, PUREGON)

Ganirelix (ANTAGON)

Gonadorelin (FACTREL, LUTREPULSE)

Goserelin (ZOLADEX)

Histrelin (VANTAS, SUPPRELIN LA)

Lanreotide (SOMATULINE LA, SOMATULINE DEPOT)

Leuprolide (LUPRON, ELIGARD)

Lutropin alfa (LUVERIS, LHADI)

Mecasermin (INCRELEX)

Menotropins (REPRONEX)

Nafarelin (SYNAREL)

Octreotide (SANDOSTATIN, SANDOSTATIN-LAR DEPOT)

Oxytocin

Pegvisomant (SOMAVERT)

Pergolide (PERMAX)

Quinagolide (NORPROLAC)

Recombinant human growth hormoneGH (ACCRETRTROPIN, GENOTROPIN, HUMATROPE, NORDITROPIN, NUTROPIN, OMNITROPE, SAIZEN, SERPSTIM, TEV-TROPIN, ZORBTIVE, NUTROPINE DEPOT)

Triptorelin (TRELSTAR DEPOT LA)

Urine-derived human chorionic gonadotropin (hCG; NOVAREL, PREGNYL, PROFASI)

Urofollitropin (uFSH; BRAVELLE, MENOPUR)

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Table Graphic Jump Location
MECHANISMS OF ACTION OF DRUGS THAT ACT ON THE HYPOTHALAMIC-PITUITARY AXIS

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