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INTRODUCTION

This chapter will be most useful after having a basic understanding of the material in Chapter 50, Chemotherapy of Protozoal Infections in Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12th Edition. In addition to the material presented here, the 12th Edition contains:

  • A detailed discussion of protozoal infections, including amebiasis, giardiasis, toxoplasmosis, trichomoniasis, cryptosporidiosis, trypanosomiasis, leishmaniasis, babesiosis, balantidiasis, Isospora belli, and microsporidia

LEARNING OBJECTIVES

  • Understand the most common protozoal infections, the clinical symptoms, and the mainstays of therapy.

  • Describe the mechanisms of action of antiprotozoal drugs.

  • Understand the treatment of giardiasis, amebiasis, and cryptosporidiosis.

  • Identify the therapeutic uses of antiprotozoal drugs.

  • Describe the toxicities and precautions to the use of antiprotozoal drugs.

DRUGS INCLUDED IN THIS CHAPTER

Amphotericin B (see Chapter 43)

Eflornithine (ORNIDYL)

Fumagillin (FUMIDIL)

8-Hydroxyquinolines (iodoquinol; YODOXIN)

Melarsoprol

Metronidazole (FLAGYL)

Miltefosine (IMPAVIDO)

Nitazoxanide (ALINA)

Nifurtimox (LAMPIT)

Benznidazole (ROCHAGAN)

Paromomycin

Pentamidine

Sodium stibogluconate

Suramin

PROTOZOAL INFECTIONS DISCUSSED IN THIS CHAPTER

Amebiasis

Giardiasis

Cryptosporidiosis

MECHANISMS OF ACTION AND RESISTANCE OF ANTI-PROTOZOAL DRUGS

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