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INTRODUCTION

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This chapter will be most useful after having a basic understanding of the material in Chapter 50, Chemotherapy of Protozoal Infections in Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12th Edition. In addition to the material presented here, the 12th Edition contains:

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  • A detailed discussion of protozoal infections, including amebiasis, giardiasis, toxoplasmosis, trichomoniasis, cryptosporidiosis, trypanosomiasis, leishmaniasis, babesiosis, balantidiasis, Isospora belli, and microsporidia

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LEARNING OBJECTIVES

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  • Understand the most common protozoal infections, the clinical symptoms, and the mainstays of therapy.

  • Describe the mechanisms of action of antiprotozoal drugs.

  • Understand the treatment of giardiasis, amebiasis, and cryptosporidiosis.

  • Identify the therapeutic uses of antiprotozoal drugs.

  • Describe the toxicities and precautions to the use of antiprotozoal drugs.

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DRUGS INCLUDED IN THIS CHAPTER

Amphotericin B (see Chapter 43)

Eflornithine (ORNIDYL)

Fumagillin (FUMIDIL)

8-Hydroxyquinolines (iodoquinol; YODOXIN)

Melarsoprol

Metronidazole (FLAGYL)

Miltefosine (IMPAVIDO)

Nitazoxanide (ALINA)

Nifurtimox (LAMPIT)

Benznidazole (ROCHAGAN)

Paromomycin

Pentamidine

Sodium stibogluconate

Suramin

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PROTOZOAL INFECTIONS DISCUSSED IN THIS CHAPTER

Amebiasis

Giardiasis

Cryptosporidiosis

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Table Graphic Jump Location
MECHANISMS OF ACTION AND RESISTANCE OF ANTI-PROTOZOAL DRUGS

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