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INTRODUCTION

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This chapter will be most useful after having a basic understanding of the material in Chapter 55, Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents in Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12th Edition. In addition to the material presented here Chapter 55 contains:

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  • Table 55-2 which provides information about the activity of most of the antibacterial agents covered in this chapter against key gram-positive pathogens

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LEARNING OBJECTIVES

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  • Understand the mechanisms of action and resistance of tetracyclines, macrolides, vancomycin, linezolid, daptomycin, and quinupristin/dalfopristin

  • Describe the unique toxicities of antibiotics that are inhibitors of bacterial protein synthesis

  • Describe the uses and untoward reactions of vancomycin

  • Identify the drug–drug interactions that occur with some of these antibiotics

  • Understand how linezolid, daptomycin, and quinupristin/dalfopristin are used to treat methicillin-resistant and vancomycin-resistant organisms

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DRUGS INCLUDED IN THIS CHAPTER

  • Azithromycin (ZITHROMAX)

  • Bacitracin

  • Chloramphenicol

  • Clarithromycin (BIAXIN, others)

  • Clindamycin (CLEOCIN PHOSPHATE, others)

  • Daptomycin (CUBICIN)

  • Doxycycline

  • Erythromycin

  • Linezolid (ZYVOX)

  • Mupirocin (BACTROBAN)

  • Polymyxin

  • Quinupristin/dalfopristin (SYNERCID)

  • Spectinomycin

  • Teicoplanin

  • Telithromycin (KETEX)

  • Tetracycline

  • Tigecycline

  • Vancomycin (VANCOCIN)

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Table Graphic Jump Location
MECHANISMS OF ACTION AND RESISTANCE OF PROTEIN SYNTHESIS INHIBITORS

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