Chapter 41: Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents

INTRODUCTION

This chapter will be most useful after having a basic understanding of the material in Chapter 55, Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents in Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12th Edition. In addition to the material presented here Chapter 55 contains:

• Table 55-2 which provides information about the activity of most of the antibacterial agents covered in this chapter against key gram-positive pathogens

LEARNING OBJECTIVES

• Understand the mechanisms of action and resistance of tetracyclines, macrolides, vancomycin, linezolid, daptomycin, and quinupristin/dalfopristin

• Describe the unique toxicities of antibiotics that are inhibitors of bacterial protein synthesis

• Describe the uses and untoward reactions of vancomycin

• Identify the drug–drug interactions that occur with some of these antibiotics

• Understand how linezolid, daptomycin, and quinupristin/dalfopristin are used to treat methicillin-resistant and vancomycin-resistant organisms