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INTRODUCTION

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This chapter is a composite of Chapters 58 and 59 in Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 12th Edition. The material presented here will be more useful after having a basic understanding of the material presented in these chapters. This chapter does not contain detailed information about all antiviral or antiretroviral agents. For the details of agents not discussed here, see Chapters 58 and 59 in the 12th Edition of Goodman and Gilman’s The Pharmacological Basis of Therapeutics. In addition to the material presented here, the 12th Edition contains:

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  • Table 58-2 which provides the nomenclature of antiviral agents

  • Figures 58-2, 58-4, 58-6, 59-2, 59-4, and 59-6 which show the chemical structures of each of the drugs discussed in this chapter

  • At the beginning of Chapter 59 in Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 12th Edition, there is an excellent overview of human immunodeficiency disease (HIV) infection and its treatment, the pathogenesis of HIV-related disease, and the principles of HIV chemotherapy

  • Table 59-1 which is a list of antiretroviral agents approved in the United States

  • Tables 59-2, 59-3, and 59-4 which provide detailed information on the pharmacokinetics of antiretroviral agents

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LEARNING OBJECTIVES

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  • Understand the treatment of herpes virus infections and the use of antiherpes drugs.

  • Know the treatment strategies for chronic hepatitis B and C infections.

  • Understand the mechanisms of action and resistance, and the therapeutic use of the anti-influenza agents.

  • Know the principles of HIV chemotherapy.

  • Know the mechanisms of action and resistance, the untoward effects, and the therapeutic uses of the drugs used to treat HIV infections.

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DRUGS INCLUDED IN THIS CHAPTER

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