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Section 9: Gynecologic and Obstetric Disorders

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Which of the following drug properties limits the ability of a drug to readily transfer across the placenta:

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A. Low protein binding

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B. Molecular weight below 500 daltons

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C. Hydrophilicity

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D. Weak base

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The answer is C.

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Which of the following types of data to evaluate drug safety during pregnancy is least likely to be available?

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A. Case study or case series

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B. Case-control study

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C. Retrospective cohort study

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D. Randomized, controlled trial

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The answer is D.

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A 36-year-old woman with an active seizure disorder is contemplating pregnancy. Your recommendation to her is:

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A. Switch antiepileptic treatment to a medication not known to cause neural tube defects

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B. Take folic acid 4 mg daily during the first trimester

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C. Take folic acid 4 mg daily before conception followed by 4 mg daily during at least the first trimester

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D. Increase dietary intake of folic acid

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The answer is C.

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A 29-year-old woman who is at week 37 is complaining of constipation for the past 3 days despite increasing her dietary fiber and water intake. Which of the following recommendations is not appropriate?

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A. Polyethylene glycol

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B. Castor oil

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C. Bisacodyl

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D. Senna

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E. None of the above is appropriate

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The answer is B.

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Which of the following interventions decreases the risk of developing preeclampsia during pregnancy in women at risk for preeclampsia?

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A. Bedrest

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B. Low-dose aspirin

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C. Oral calcium supplementation

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D. Oral lisinopril

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E. Intravenous magnesium sulfate infusion

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The answer is B.

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For a woman at 34 weeks of gestation with an acute deep vein thrombosis, the treatment of choice is:

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