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Section 9: Gynecologic and Obstetric Disorders

Which of the following drug properties limits the ability of a drug to readily transfer across the placenta:

A. Low protein binding

B. Molecular weight below 500 daltons

C. Hydrophilicity

D. Weak base

The answer is C.

Which of the following types of data to evaluate drug safety during pregnancy is least likely to be available?

A. Case study or case series

B. Case-control study

C. Retrospective cohort study

D. Randomized, controlled trial

The answer is D.

A 36-year-old woman with an active seizure disorder is contemplating pregnancy. Your recommendation to her is:

A. Switch antiepileptic treatment to a medication not known to cause neural tube defects

B. Take folic acid 4 mg daily during the first trimester

C. Take folic acid 4 mg daily before conception followed by 4 mg daily during at least the first trimester

D. Increase dietary intake of folic acid

The answer is C.

A 29-year-old woman who is at week 37 is complaining of constipation for the past 3 days despite increasing her dietary fiber and water intake. Which of the following recommendations is not appropriate?

A. Polyethylene glycol

B. Castor oil

C. Bisacodyl

D. Senna

E. None of the above is appropriate

The answer is B.

Which of the following interventions decreases the risk of developing preeclampsia during pregnancy in women at risk for preeclampsia?

A. Bedrest

B. Low-dose aspirin

C. Oral calcium supplementation

D. Oral lisinopril

E. Intravenous magnesium sulfate infusion

The answer is B.

For a woman at 34 weeks of gestation with an acute deep vein thrombosis, the treatment of choice is:


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