Section 10: Urologic Disorders
Which of the following medications is administered as a tablet which should be put on the tongue and allowed to be dissolved? It should not be swallowed?
After three doses of tadalafil 10 mg taken on demand on three separate occasions, the patient returns to the physician's office to complain that the medication is not working. His erectile dysfunction has not responded to treatment. The most appropriate action that the physician should take at this time is:
A. Discontinue tadalafil and switch the patient to a vacuum erection device.
B. Lower the tadalafil dose to 5 mg and instruct the patient to take it daily, not on demand.
C. Continue with tadalafil 10 mg on demand for a total of 7-8 doses, and review the instructions for proper use.
D. Increase the tadalafil dose to 20 mg and instruct the patient to try this the next time.
E. Combine tadalafil 10 mg with intracavernosal alprostadil and instruct the patient to take both on demand.
If a phosphodiesterase type 5 inhibitor is taken with a potent CYP 3A4 inducer, the drug interaction may result in:
A. Decreased efficacy of the phosphodiesterase type 54 inhibitor.
C. Increased blood pressure
Which one of the following statements about phosphodiesterase type 5 inhibitors is correct?
A. If a patient is taking an alpha-adrenergic antagonist, blood pressure should be stabilized before starting the phosphodiesterase type 5 inhibitor.
B. If the patient has taken a nitrate, all phosphodiesterase type 5 inhibitors should be held for at least one week.
C. Sildenafil prolongs the QT interval in patients taking quinidine or procainamide.
D. The combination of erythromycin and a phosphodiesterase type 5 inhibitor will result in severe coughing.