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Section 11: Immunologic Disorders

Which of the following individuals would be at highest risk for developing idiopathic SLE?

A. 20-year-old African American female

B. 25-year-old white female

C. 30-year-old Hispanic male

D. 40-year-old Asian male

The answer is A.

There is evidence that SLE can be precipitated in a genetically susceptible individual by:

A. Epstein–Barr virus

B. Pesticides

C. Ultraviolet light

D. All of the above

The answer is D.

A patient is being considered for a trial of a new drug for lupus. She has a malar rash, oral ulcers, and joint tenderness. The study requires that participants fulfill the 2012 Systemic Lupus International Collaborating Clinics Classification Criteria for SLE. What additional finding would qualify this individual for the trial?

A. Anticardiolipin antibody

B. Proteinuria of 1 g in 24 hours

C. Seizures

D. White blood cell count of 5,000/mm3

The answer is A.

Patients with SLE should be encouraged to stop smoking. It has been associated with all of the following except:

A. Decreased effectiveness of hydroxychloroquine

B. Decreased titers of anti-double-stranded DNA

C. Increased incidence of hemorrhagic cystitis with cyclophosphamide

D. Increased incidence of rash with scarring

The answer is B.

Which of the following drugs decreases survival of B cells by inhibiting B-lymphocyte stimulator?

A. Abatacept

B. Belimumab

C. Rituximab

D. Tocilizumab

The answer is B.

A 20-year-old African American woman develops Class III lupus nephritis. What is the recommended induction treatment for her disease?

A. High-dose IV cyclophosphamide

B. Low-dose IV cyclophosphamide

C. Mycophenolate mofetil

D. Rituximab

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