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Section 12: Rheumatologic Disorders

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Risk factors for the development of osteoarthritis (OA) include:

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A. Smoking

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B. Participation in running

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C. Being underweight

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D. Advanced age

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E. b and d

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The answer is D.

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Patient education for OA, such as programs in which volunteers regularly contact patients

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A. Has not yet been demonstrated to provide benefit to OA patients

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B. Is too expensive to recommend for general use by OA patients

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C. Should emphasize the "wear and tear" nature of OA as part of the educational message

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D. Has been shown to improve pain and functional status of OA patients

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E. All of the above

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The answer is D.

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Matrix metalloproteinases (MMPs)

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A. Are naturally occurring chemokines that work primarily by recruiting neutrophils and macrophages to the inflamed synovium

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B. Help trigger degradation of articular cartilage by cleaving peptide bonds in proteoglycans

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C. Are stimulated by tissue inhibitors of metalloproteinases (TIMPS)

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D. Must be activated before they can ease the pain of OA

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E. b and c

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The answer is B.

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Which of the following are required for an accurate and appropriate diagnosis of OA?

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A. Patient history and physical examination

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B. Patient history, physical examination, and radiologic evaluation

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C. Physical examination and magnetic resonance imaging

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D. Patient history, physical examination, and positive response to pharmacologic treatment

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E. Any of the above is accurate and appropriate

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The answer is B.

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Acetaminophen

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A. Is recommended as an appropriate initial treatment in OA

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B. Should be given on a scheduled basis for optimal pain control

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C. Can be associated with hepatotoxicity at doses below 4 g/day

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D. Provides mild analgesia

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