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Cancer Chemotherapy and Treatment

Chapter 88. Cancer Chemotherapy and Treatment

Which of the following most correctly describes the pattern of cell growth in tumors according to the Gompertzian growth model?

A. The growth rate of tumor cells decreases steadily as the tumor grows larger.

B. The growth rate of tumor cells increases steadily as the tumor grows larger.

C. The growth rate of tumor cells is constant.

D. The growth rate of tumor cells follows an exponential growth pattern.

E. None of the above.

In the multistep model of carcinogenesis, which of the following stages is reversible and is a target for cancer prevention strategies?

A. Initiation

B. Promotion

C. Transformation

D. Progression

E. Conversion

Individuals homozygous for UTT1A1*28 are at an increased risk of febrile neutropenia and diarrhea and should be considered for upfront dose reduction when receiving which of the following agents?

A. Ifosfamide

B. Cabazitaxel

C. Regorafenib

D. Irinotecan

E. Ramicirumab

All of the following agents are vesicants and are likely to produce severe tissue damage if extravasated EXCEPT:

A. Doxorubicin

B. Fluorouracil

C. Vincristine

D. Mechlorethamine

E. Dactinomycin

Patients with NSCLC that is ALK positive as detected by an FDA-approved test would benefit from which of the following agents?

A. Vemurafenib

B. Imatinib

C. Crizotinib

D. Cetuximab

E. Ibrutinib

Which of the following agents produces laryngeal bronchospasm as an acute neurotoxic effect, which can be exacerbated by cold temperatures or cold food/drinks?

A. Carboplatin

B. Cisplatin

C. Oxaliplatin

D. Paclitaxel

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