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Chapter 67. Coagulation and Platelet Disorders

Extrinsic pathway of anticoagulation involves:

A. Factor XII

B. Factor VII

C. Factor IX

D. Factor XI

Which of the following statements is true?

A. Each unit of factor (F) VIII replacement administered per kilogram of body weight raises the plasma FVIII level 1% (0.01 IU/mL [10 IU/L]).

B. Each unit of FVIII replacement administered per kilogram of body weight raises the plasma FVIII level 2% (0.02 IU/mL [20 IU/L]).

C. Each unit of FIX replacement administered per kilogram of body weight yields a 0.5% rise in plasma (0.005 IU/mL [5 IU/L]) FIX level.

D. Each unit of FIX replacement administered per kilogram of body weight yields a 2% rise in plasma (0.02 IU/mL [20 IU/L]) FIX level.

E. Each unit of FIX replacement administered per kilogram of body weight yields a 3% rise in plasma (0.03 IU/mL [30 IU/L]) FIX level.

To increase the FVIII level from 0% to 80% in a 50-kg hemophiliac, _____ units of FVIII should be administered.

A. 500

B. 3000

C. 4000

D. 1600

E. 2000

Which of the following is the medication of choice to control mild joint pain associated with joint destruction in patients with hemophilia?

A. Ibuprofen

B. Acetaminophen

C. Oxycodone

D. Naproxen

E. Aminocaproic acid

Which of the following is the best approach to treating a nonbleeding 60-kg hemophilia patient with 3 BU/mL (3000 BU/L) of factor VIII inhibitor?

A. 7200 mcg of recombinant factor VIIa IV every 2 hours

B. 4500 units of aPCC IV twice daily

C. Immune tolerance induction, factor VIII replacement per levels

D. 6000 porcine units of recombinant porcine factor VIII IV daily

E. 6000 units of Advate IV twice daily

Which ...

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