Skip to Main Content

Chapter 81. Osteomyelitis

An 82-year-old woman with no known allergies was admitted to the hospital to receive surgical and medical management for suspected osteomyelitis of the tibia. During surgical debridement, a bone biopsy was obtained for culture and histopathology. The microbiology laboratory reported Staphylococcus aureus, susceptible to vancomycin, linezolid, daptomycin, trimethoprim-sulfamethoxazole but resistant to penicillin, oxacillin, ciprofloxacin, erythromycin, and clindamycin.

Select an appropriate intravenous antimicrobial regimen for this patient.

A. Linezolid

B. Levofloxacin

C. Nafcillin

D. Trimethoprim-sulfamethoxazole

E. Vancomycin

An 82-year-old woman with no known allergies was admitted to the hospital to receive surgical and medical management for suspected osteomyelitis of the tibia. During surgical debridement, a bone biopsy was obtained for culture and histopathology. The microbiology laboratory reported Staphylococcus aureus, susceptible to vancomycin, linezolid, daptomycin, trimethoprim-sulfamethoxazole but resistant to penicillin, oxacillin, ciprofloxacin, erythromycin, and clindamycin.

Which laboratory parameter(s) should be monitored weekly in this patient receiving intravenous antibiotic therapy?

A. Liver function tests

B. BUN/SCr

C. Vancomycin trough

D. A and B

E. B and C

An 82-year-old woman with no known allergies was admitted to the hospital to receive surgical and medical management for suspected osteomyelitis of the tibia. During surgical debridement, a bone biopsy was obtained for culture and histopathology. The microbiology laboratory reported Staphylococcus aureus, susceptible to vancomycin, linezolid, daptomycin, trimethoprim-sulfamethoxazole but resistant to penicillin, oxacillin, ciprofloxacin, erythromycin, and clindamycin.

Response to therapy can be evaluated by the following laboratory test(s):

A. CPK

B. CRP

C. ESR

D. A and B

E. B and C

An 82-year-old woman with no known allergies was admitted to the hospital to receive surgical and medical management for suspected osteomyelitis of the tibia. During surgical debridement, a bone biopsy was obtained for culture and histopathology. The microbiology laboratory reported Staphylococcus aureus, susceptible to vancomycin, linezolid, daptomycin, trimethoprim-sulfamethoxazole but resistant to penicillin, oxacillin, ciprofloxacin, erythromycin, and clindamycin.

Following 3 weeks of intravenous therapy with clinical improvement, the clinician would now like to switch to oral therapy. What do you recommend?

A. Daptomycin

B. Linezolid

...

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.