1.2.14: Develop and implement individualized treatment plans, taking into consideration routes and methods of administration, dosage forms, and delivery systems
Which of the following is a correct statement regarding administering drugs via an enteral feeding tube?
(A) Extended-release medications are always preferable to immediate-release dosage forms.
(B) As long as tablets are crushed very finely they will retain their pharmacokinetic properties.
(C) All drugs that a patient receives should be given simultaneously to minimize feeding interruptions.
(D) Liquid medications may interact with nutritional formula and clog the feeding tube.
The correct answer is (D).
Some liquid medications have physical incompatibilities with enteral nutrition products, which may thicken the products or form a gel (D).
Immediate release dosage forms are preferred for feeding tube administration (A), as crushing extended-release products can cause all of the medication to be released immediately instead of over the intended extended timeframe. Many tablets cannot be crushed at all, and crushing often changes the pharmacokinetic properties of the tablet (B). Even in patients taking medications by mouth, there may be incompatibilities (C). These same restrictions apply when administering medications per tube.
What is the recommended route of administration for ampicillin, for the treatment of bacterial meningitis?
IV antibiotics (A) are recommended for therapy of patients with bacterial meningitis, to ensure adequate concentrations.
Oral administration (B) will not likely produce sufficiently high concentrations of the ampicillin. Intramuscular administration (C) is not optimal for treatment or to ensure adequate drug concentrations. This route, although not optimal, can be used in urgent situations until IV access can be obtained. Intrathecal administration (D) is not required for ampicillin administration, due to adequate concentrations being achieved with intravenous administration.
Topic: Central Nervous System Infections
Which of the following is a correct statement regarding administration of medications via nasogastric tubes?
(A) The medication must be compatible with isotonic fluids.
(B) Tablets must be fully crushed and mixed with 15 to 30 mL of water.
(C) The tube must be flushed with 250 mL of water before and after medication administration.
(D) Capsule beads should be crushed and mixed with 15 to 30 mL of water.
Tablets should be crushed, ground ...