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2.2.1: Compound sterile and nonsterile products, considering techniques, procedures, and equipment for drug preparation, compounding, and administration of sterile products

When preparing an IV formulation of amphotericin B deoxycholate (desoxycholate), the lyophilized amphotericin B powder must first be reconstituted with sterile water. What type of IV fluid must the reconstituted amphotericin B be placed in for IV administration?

(A) 0.9% sodium chloride

(B) 5% dextrose in water

(C) Lactated Ringer's solution

(D) 0.45% sodium chloride

The correct answer is (B).

This solution will maintain the micellular distribution that is required for IV amphotericin B desoxycholate.

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