Skip to Main Content

We have a new app!

Take the Access library with you wherever you go—easy access to books, videos, images, podcasts, personalized features, and more.

Download the Access App here: iOS and Android. Learn more here!



  • Bipolar disorder is a lifelong illness, which requires adherence to medications to prevent repeated episodes.

  • Polypharmacy is the rule in the treatment of bipolar disorder, rather than the exception.

  • Adverse effects, drug interactions, and cost of medications can lead to nonadherence. Medication therapy management (MTM) providers should be watchful of nonadherence and work with the patient to create a regimen that is both tolerable and affordable.

  • Inclusion of the patient in a therapeutic alliance can increase adherence to treatment and medications.


Bipolar disorder (previously known as manic-depressive disorder) is a cyclic mood disorder characterized by recurrent fluctuations in mood, energy, and behavior.1,2 Bipolar disorder is a lifelong illness with a variable course, which requires both nonpharmacologic and pharmacologic treatment.1,2 Episodes of bipolar disorder include not only major depression but also hypomania, mania, and mixed (Table 15-1).

TABLE 15-1abEvaluation and Diagnosis of Mood Episodes

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.