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Chapter 13. Lung Cancer

What is the brand name of crizotinib?

a. Xalkori

b. Opdivo

c. Cyramza

d. Iressa

Answer a is correct. The brand name of crizotinib is Xalkori.

Answer b is incorrect. Opdivo is the brand name of nivolumab.

Answer c is incorrect. Cyramza is the brand name of ramucirumab.

Answer d is incorrect. Iressa is the brand name of gefitinib.

A 59-year-old man with recently diagnosed limited-stage small-cell lung cancer comes to clinic for treatment. Which of the following would be the most appropriate treatment for him?

a. Cisplatin plus vinorelbine

b. Surgery followed by adjuvant cisplatin plus etoposide

c. Carboplatin, paclitaxel, and bevacizumab

d. Cisplatin and etoposide along with concurrent thoracic radiation therapy

Answer d is correct. For limited stage small-cell lung cancer (SCLC) to maximize survival, one should utilize concurrent thoracic radiation therapy and cisplatin plus etoposide.

Answer a is incorrect. Cisplatin and vinorelbine is a potential adjuvant treatment for squamous NSCLC.

Answer b is incorrect. Surgery is not recommended for the treatment of SCLC.

Answer c is incorrect. Carboplatin, paclitaxel, and bevacizumab are the regimens used for the treatment of advanced non-squamous NSCLC.

A 60-year-old woman comes into your pharmacy to pick up her usual prescription for her maintenance medications. She asks you about taking vitamin supplements to decrease her risk of lung cancer. Her social history is significant for smoking a pack of cigarettes a day for 25 years, but she stopped 3 years ago. Based upon this information, you should recommend which of the following?

a. β-Carotene

b. Vitamin E plus β-carotene

c. β-Carotene plus retinyl palmitate

d. No supplement is recommended

Answer d is correct. To date, randomized trials of chemopreventive agents (eg, vitamin E, β-carotene, and retinyl palmitate) have not demonstrated a benefit in preventing lung cancer in patients at high risk for developing lung cancer. In two randomized clinical trials, β-carotene has been associated with an increased risk of lung cancer and mortality in patients at high risk for developing lung cancer.

Answer a is incorrect. In two randomized clinical trials, β-carotene has been associated with an increased risk of lung ...

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