Chapter 28. Opportunistic Infections
Pyrimethamine has been shown to cause bone marrow suppression. Which agent can be given in conjunction with pyrimethamine to lessen the suppressive effects?
Answer d is correct. Leucovorin has similar functionality when used with methotrexate.
Answer a is incorrect. Vitamin B12 will not have an effect on the bone marrow suppression of pyrimethamine.
Answer b is incorrect. Levofloxacin, a fluoroquinolone, has not been shown to decrease bone marrow suppression.
Answer c is incorrect. Dapsone prevents bacterial folic acid synthesis but has not been demonstrated to be helpful in bone marrow suppression.
What is the brand name for moxifloxacin?
Answer a is correct. Avelox is the brand name of moxifloxacin.
Answer b is incorrect. Septra is the brand name of sulfamethoxazole and trimethoprim.
Answer c is incorrect. Mepron is the brand name of atovaquone.
Answer d is incorrect. Aczone is the brand name of dapsone.
JK is a patient at a local clinic with a recent diagnosis of AIDS. His past medical history includes hypertension, dyslipidemia, and depression. Medications include losartan, atorvastatin, and escitalopram. Labs include: CD4 count of 120 cells/mm3, serum and potassium 4.8 mEq/L (increased from 3.5 mEq/L). Which agent is recommended as a preferred therapy for PCP prophylaxis?
Answer b is correct. TMP-SMX is the preferred therapy for PCP prophylaxis despite its potassium retaining capabilities.
Answer a is incorrect. Clindamycin, a lincosamide, is an alternative therapy for PCP prophylaxis.
Answer c is incorrect. Amikacin, an aminoglycoside, is not preferred therapy for PCP prophylaxis.
Answer d is incorrect. Levofloxacin, a fluoroquinolone, is not considered preferred therapy for PCP prophylaxis.
LZ is a 52-year-old patient admitted to the hospital with complications of AIDS. The nurse informs the pharmacy resident that he is being treated for a PJP infection. She is unclear of the duration of therapy and asks the pharmacy resident for clarification. ...