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INTRODUCTION

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CYP3A4 SUBSTRATES

A

Alfentanil (Alfenta)

Alfuzosin (Uroxatral)

Almotriptan (Axert)

Alprazolam (Xanax)

Amiodarone (Cordarone)

Amlodipine (Norvasc)

Aprepitant (Emend)

Atazanavir (Reyataz)

Atorvastatin (Lipitor)

B

Bepridil (Vascor)

Bexarotene (Targretin)

Bosentan (Tracleer)

Bromocriptine (Parlodel)

Budesonide (Entocort)

Buprenorphine (Subutex)

Bupropion (Zyban, Wellbutrin, Voxra)

C

Carbamazepine (eg, Tegretol)

Cevimeline (Evoxac)

Cilostazol (Pletal)

Cisapride (Propulsid)

Clarithromycin (Biaxin)

Clonazepam (Klonopin)

Clopidogrel (Plavix)

Colchicine

Cyclophosphamide (Cytoxan)

Cyclosporine (Neoral)

D

Dapsone (Avlosulfon)

Darunavir (Prezista)

Dasatinib (Sprycel)

Delavirdine (Rescriptor)

Dexamethasone (Decadron)

Dihydroergotamine

Diltiazem (Cardizem)

Disopyramide (Norpace)

Docetaxel (Taxotere)

Donepezil (Aricept)

Doxorubicin (Adriamycin)

Droperidol

Dutasteride (Avodart)

E

Ebastine (Kestine)

Efavirenz (Sustiva)

Eletriptan (Relpax)

Eplerenone (Inspra)

Ergotamine (Ergomar)

Erlotinib (Tarceva)

Erythromycin

Estazolam (ProSom)

Eszopiclone (Lunesta)

Ethinyl Estradiol

Ethosuximide (Zarontin)

Etoposide (Vepesid)

Exemestane (Aromasin)

F

Felodipine (Plendil)

Fentanyl (Sublimaze)

Finasteride (Proscar)

Flurazepam (Dalmane)

Fosamprenavir (Lexiva)

G

Galantamine (Reminyl)

Gefitinib (Iressa)

Granisetron (Kytril)

H

Halofantrine (Halfan)

I

Ifosfamide (Ifex)

Imatinib (Gleevec)

Indinavir (Crixivan)

Irinotecan (Camptosar)

Isradipine (DynaCirc)

Itraconazole (Sporanox)

Ixabepilone (Ixempra)

K

Ketoconazole (Nizoral)

L

Lapatinib (Tykerb)

Levomethadyl (Orlaam)

Loperamide (Imodium)

Lopinavir (Kaletra)

Loratadine (Claritin)

Lovastatin (Mevacor)

M

Maraviroc (Selzentry)

Mefloquine (Lariam)

Methylprednisolone

Midazolam (Versed)

Mifepristone (Mifeprex)

Modafinil (Provigil)

N

Nefazodone

Nevirapine (Viramune)

Nicardipine (Cardene)

Nifedipine (Adalat)

Nimodipine (Nimotop)

Nisoldipine (Sular)

Nitrendipine (Baypress)

O

Oxybutynin (Ditropan)

Oxycodone (OxyContin)

P

Paclitaxel (Taxol)

Paricalcitol (Zemplar)

Pimozide (Orap)

Pioglitazone

Praziquantel (Biltricide)

Prednisolone

Prednisone

Propoxyphene (Darvon)

Q

Quazepam (Doral)

Quetiapine (Seroquel)

Quinacrine

Quinidine

Quinine

R

Ranolazine (Ranexa)

Repaglinide (Prandin)

Rifabutin (Rimactane)

Ritonavir (Norvir)

S

Saquinavir (Invirase)

Sibutramine (Meridia)

Sildenafil (Viagra)

Simvastatin (Zocor)

Sirolimus (Rapamune)

Solifenacin (Vesicare)

Sufentanil (Sufenta)

Sunitinib (Sutent)

T

Tacrolimus (Prograf)

Tadalafil (Cialis)

Tamoxifen (Nolvadex)

Tamsulosin (Flomax)

Teniposide (Vumon)

Testosterone

Tiagabine (Gabitril)

Tinidazole (Tindamax)

Tipranavir (Aptivus)

Topiramate (Topamax)

Triazolam (Halcion)

V

Vardenafil (Levitra)

Verapamil (Calan)

Vinblastine (Velbane)

Vincristine (Oncovin)

Z

Ziprasidone (Geodon)

Zolpidem (Ambien)

Zonisamide (Zonegran)

Zopiclone (Imovane)

Contain "sulfa" moiety

*This is not a complete listing.

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...
  STRONG CYP3A4 INHIBITORS OTHER CYP3A4 INHIBITORS STRONG CYP3A4 INDUCERS OTHER CYP3A4 INDUCERS
DRUG CLASS Increase the plasma concentrations of the CYP3A4 substrate medications Reduce plasma concentrations of CYP3A4 substrates
Alkylating Agents      

Cyclophosphamide

Ifosfamide

Antiarrhythmics  

Amiodarone

Dronedarone

   
Antibiotics

Clarithromycin

Telithromycin

Chloramphenicol

Ciprofloxacin

Doxycycline

Erythromycin

Quinupristin

   
Antidepressants Nefazodone

Fluoxetine

Fluvoxamine

Reboxetine

   
Antiemetic   Aprepitant    
Antiepileptics    

Carbamazepine

Fosphenytoin

Phenytoin

Phenobarbital

Primidone

Oxcarbazepine

Topiramate
Antifungals

Ketoconazole

Itraconazole

Fluconazole

Miconazole

Posaconazole

Voriconazole

   
Antimycobacterial   Isoniazid

Rifabutine

Rifapentine

Rifampicin

 
Antineoplastic  

ceritinib

Dasatinib

Imatinib

Lapatinib

Nilotinib

Tamoxifen

   
Antipsychotic   Quetiapine    
Antivirals

PIs

Atazanavir

Darunavir

Indinavir

Lopinavir

Nelfinavir

Ritonavir

Saquinavir

Tipranavir

NNRTIs

Delavirdine

 

PIs

Amprenavir

Fosamprenavir

Other

Cobicistat

Nevirapin

Efavirenz

Etravirine

CCBs  

Diltiazem

Verapamil

   
Contraceptives  

Desogestrel

Ethinylestradiol

   
Corticosteroids   Methylprednisolone   Dexamethasone
Endotheline Antagonist       Bosentan
H2 Receptor Antagonist   Cimetidine    
Immunosuppressi ve   Cyclosporine    
Vasopressin receptor antagonist   Conivaptan

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