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Source: Lee M, Sharifi R. Erectile dysfunction. In: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM. Pharmacotherapy: A Pathophysiologic Approach. 10th ed. New York, NY: McGraw-Hill; 2017. http://accesspharmacy.mhmedical.com/content.aspx?bookid=1861§ionid=146067529. Accessed March 7, 2017.
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CONDITION/DISORDER SYNONYM
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Interconnected sinuses in two corpora cavernosa in penis fill with blood to produce erection.
Acetylcholine works with other neurotransmitters (ie, cyclic guanylate monophosphate, cyclic adenosine monophosphate, and vasoactive intestinal polypeptide) to produce penile arterial vasodilation and ultimately erection.
Organic ED associated with diseases that.
Compromise vascular flow to corpora cavernosum (eg, peripheral vascular disease, arteriosclerosis, and essential hypertension)
Impair nerve conduction to brain (eg, spinal cord injury and stroke)
Impair peripheral nerve conduction (eg, diabetes mellitus)
Secondary ED associated with hypogonadism.
Psychogenic ED associated with.
Malaise.
Reactive depression.
Performance anxiety.
Sedation.
Alzheimer disease.
Hypothyroidism.
Mental disorders.
Social habits (eg, cigarette smoking and excessive ethanol intake) and medications (Table 1) can also cause ED
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