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Source: Chan A, Sessions J. Lymphomas. In: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM, eds. Pharmacotherapy: A Pathophysiologic Approach. 10th ed. New York, NY: McGraw-Hill; 2017. http://accesspharmacy.mhmedical.com/content.aspx?bookid=1861§ionid=133894009. Accessed April 13, 2017.
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Derived from monoclonal proliferation of malignant B or, less commonly, T lymphocytes and their precursors.
Current classification schemes characterize Non-Hodgkin lymphomas (NHLs) according to cell of origin, clinical features, and morphologic features.
World Health Organization (WHO) classification terms:
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Certain infections associated with development of lymphoma:
Congenital and acquired immunodeficiency states.
Exposure to herbicides, chemical solvents, and dyes.
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CLINICAL PRESENTATION
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Adenopathy can be localized or generalized.
Involved nodes painless, rubbery, and discrete, and usually located in cervical and supraclavicular regions.
Constitutional (B symptoms) in ~40% of patients.
Fever.
Drenching night sweats.
Weight loss.
Extranodal disease in 10–35% of patients at diagnosis.
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MEANS OF CONFIRMATION AND DIAGNOSIS
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DIAGNOSTIC PROCEDURES
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DIFFERENTIAL DIAGNOSIS
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TREATMENT: GENERAL APPROACH
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