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Source: Chan CYJ, Frie-Jones M. Sickle cell disease. In: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM, eds. Pharmacotherapy: A Pathophysiologic Approach. 10th ed. New York, NY: McGraw-Hill; 2017. http://accesspharmacy.mhmedical.com/content.aspx?bookid=1861§ionid=135145372. Accessed on May 17, 2017.
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Clinical manifestations of SCD attributable to:
Impaired circulation.
RBC destruction.
Stasis of blood flow.
Above problems directly related to RBC polymerization.
Other factors responsible for clinical manifestations of SCD
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Most common in people with African heritage.
About 2 million Americans have SCT with a prevalence rate of 1 in 13 African Americans and 1 in 100 Hispanics.
Incidence of sickle cell gene in population correlates with historical incidence of malaria.
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PREVENTION AND SCREENING
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CLINICAL PRESENTATION
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