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Section 1: Foundation Issues

Clearance determines

A. The time to reach steady state

B. The loading dose required to achieve the desired steady-state concentration

C. The maintenance dose required to achieve the desired steady-state concentration

D. The dosage interval

E. A and D

The answer is C

Volume of distribution determines

A. The time to reach steady state

B. The loading dose required to achieve the desired steady-state concentration

C. The maintenance dose required to achieve the desired steady-state concentration

D. The dosage interval

E. A and D

The answer is B

Half-life determines

A. The time to reach steady-state

B. The loading dose required to achieve the desired steady-state concentration

C. The maintenance dose required to achieve the desired steady-state concentration

D. The dosage interval

E. A and D

The answer is E

The clearance is

A. Dependent upon the value of volume of distribution

B. Dependent upon the value of half-life

C. A function of the blood flow to clearing organs and the efficiency of the organ in extracting the drug

D. A function of the physiologic volume of blood and tissues and how the drug binds in blood and tissues

E. A and B

The answer is C

The volume of distribution is

A. Dependent upon the value of clearance

B. Dependent upon the value of half-life

C. A function of the blood flow to clearing organs and the efficiency of the organ in extracting the drug

D. A function of the physiologic volume of blood and tissues and how the drug binds in blood and tissues

E. A and B

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