Sections View Full Chapter Figures Tables Videos Full Chapter Figures Tables Videos Supplementary Content +++ INTRODUCTION ++Table Graphic Jump LocationTABLE A7-1Drugs That Induce ApneaView Table||Download (.pdf) TABLE A7-1 Drugs That Induce Apnea Mechanism Relative Frequency of Reactions Central nervous system depression Narcotic analgesics F Barbiturates F Benzodiazepines F Other sedatives and hypnotics I Tricyclic antidepressants R Phenothiazines R Ketamine R Promazine R Anesthetics R Antihistamines R Alcohol R Levodopa R Oxygen R Respiratory muscle dysfunction Aminoglycoside antibiotics I Polymyxin antibiotics I Neuromuscular blockers I Quinine R Digitalis R Myopathy Corticosteroids F Diuretics I Aminocaproic acid R Clofibrate R F, frequent; I, infrequent; R, rare. ++Table Graphic Jump LocationTABLE A7-2Drugs That Induce BronchospasmView Table||Download (.pdf) TABLE A7-2 Drugs That Induce Bronchospasm Mechanism Relative Frequency of Reactions Anaphylaxis (IgE-mediated) Penicillins F Sulfonamides F Serum F Cephalosporins F L-Asparaginase F Papain F Pancreatic extract I Psyllium I Subtilase I Tetracyclines I Allergen extracts I Cimetidine R Direct airway irritation N-acetylcysteine F Bisulfite F Smoke F Smoke inhaled steroids I Acetate R Crromolyn R Precipitating IgG antibodies β-Methyldopa R Carbamazepine R Spiramycin R Cyclooxygenase inhibition Aspirin/NSAIDs F Phenylbutazone I Acetaminophen R Anaphylactoid mast-cell degranulation Iodinated-radiocontrast media I Benzalkonium chloride I Opioid analgesics I Iron-dextran complex I Local anesthetics I Steroidal anesthetics I Platinum R Pancuronium bromide R Ethylenediamine R Pharmacologic effects β-Adrenergic agonists I-F Cholinergic stimulants I Anticholinesterases R α-Adrenergic receptor blockers R Ethylenediamine tetraacetic acid R Unknown mechanisms ACE inhibitors I Monosodium glutamate I Anticholinergics R Hydrocortisone R Isoproterenol R Piperazine R Tartrazine R Sulfinpyrazone R Zinostatin R Losartan R ACE, angiotensin-converting enzyme; F, frequent; I, infrequent; Ig, immunoglobulin; NSAIDs, nonsteroidal anti-inflammatory drugs; R, rare. ++Table Graphic Jump LocationTABLE A7-3Tolerance of Anti-Inflammatory and Analgesic Drugs in Aspirin-Induced AsthmaView Table||Download (.pdf) TABLE A7-3 Tolerance of Anti-Inflammatory and Analgesic Drugs in Aspirin-Induced Asthma Cross-Reactive Drugs Drugs with No Cross-Reactivity Diclofenac Acetaminophena Diflunisal Benzydamine Fenoprofen Chloroquine Flufenamic acid Choline salicylate Flurbiprofen Corticosteroids Hydrocortisone hemisuccinate Dextropropoxyphene Ibuprofen Phenacetina Indomethacin Salicylamide Ketoprofen Sodium salicylate Mefenamic acid Naproxen Noramidopyrine Oxyphenbutazone Phenylbutazone Piroxicam Sulindac Sulfinpyrazone Tartrazine Tolmetin aA very small percentage (5%) of patients with aspirin-hypersensitivity react to acetaminophen and phenacetin. ++Table Graphic Jump LocationTABLE A7-4Drugs That Induce Pulmonary EdemaView Table||Download (.pdf) TABLE A7-4 Drugs That Induce Pulmonary Edema Mechanism Relative Frequency of Reactions Cardiogenic pulmonary edema Excessive intravenous fluids F Blood and plasma transfusions F Corticosteroids F β2-Adrenergic agonists I Sodium diatrizoate R Hypertonic intrathecal saline R Phenylbutazone R Noncardiogenic pulmonary edema Heroin F Methadone I Morphine I Oxygen I Propoxyphene R Ethchlorvynol R Chlordiazepoxide R Salicylate R Hydrochlorothiazide R Triamterene + hydrochlorothiazide R Leukoagglutinin reactions R Iron–dextran complex R Methotrexate R Cytosine arabinoside R Nitrofurantoin R Dextran 40 R Fluorescein R Amitriptyline R Colchicine R Nitrogen mustard R Epinephrine R Metaraminol R Bleomycin R Iodide R Cyclophosphamide R VM-26 R F, frequent; I, infrequent; R, rare. ++Table Graphic ... Your MyAccess profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'. Please click ‘Continue’ to continue the affiliation switch, otherwise click ‘Cancel’ to cancel signing in. Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Username Error: Please enter User Name Password Error: Please enter Password Forgot Username? Forgot Password? Sign in via OpenAthens Sign in via Shibboleth