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Chapter 44. Hepatitis

Select the most common mode of transmission for the hepatitis A virus (HAV).

a. Blood

b. Fecal–oral route

c. Perinatal exposure

d. Semen

Answer b is correct. The fecal–oral route is the most common mode of transmission of HAV and often occurs through contact with contaminated food, poor hygienic practices, and in poorly developed countries.

Answer a is incorrect. Intravenous drug users can acquire HAV through exposure to HAV infected blood but this is not a common mode of transmission.

Answer c is incorrect. Perinatal transmission is not associated with HAV, but is infrequently associated with hepatitis B virus (HBV) and very rarely for hepatitis C virus (HCV).

Answer d is incorrect. Transmission of viral hepatitis from semen is not associated with HAV, but is rarely associated with other viral hepatitis types.

Which of the following forms of viral hepatitis can be cured with drug therapy?

a. Chronic hepatitis A.

b. Chronic hepatitis B.

c. Chronic hepatitis C.

d. Viral hepatitis can never be cured.

Answer c is correct. Hepatitis C can be cured if a patient has no measurable hepatitis C virus (HCV) 6 months after completing treatment.

Answer a is incorrect. Hepatitis A is an acute infection and patients eventually clear the virus. Hepatitis A virus (HAV) does not develop into a chronic form.

Answer b is incorrect. Chronic hepatitis B cannot be cured with drug therapy. The goals are to suppress the viral load and to prevent complications (eg, cirrhosis and hepatocellular carcinoma).

Answer d is incorrect. Hepatitis C virus (HCV) can be cured.

Which of the following represents a rare side effect associated with Twinrix (hepatitis A/B vaccine)?

a. Stevens-Johnson syndrome

b. Neuroleptic syndrome

c. Guillain-Barré syndrome

d. Red-man syndrome

Answer c is correct. Guillain-Barré syndrome is a rare side effect associated with Twinrix.

Answer a is incorrect. Stevens-Johnson syndrome is not a reported side effect of Twinrix.

Answer b is incorrect. Neuroleptic syndrome is not a reported side effect of Twinrix.

Answer d is incorrect. Red-man's syndrome is not a reported side effect of Twinrix.

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