Chapter 60: Cannabinoid Drugs
Activation of the CB1 receptor on neurons results in
(A) Decreased calcium influx
(B) Increased protein kinase C (PKC)
(C) Decreased potassium efflux
(D) Increased protein kinase A (PKA)
CB1 receptors are G1/0-coupled and reduce cAMP; they indirectly reduce calcium influx. The answer is A.
CB2 receptors are mainly located on
(A) Astrocytes of the CNS
(B) Endoplasmic reticulum
(E) Neurons of the peripheral nervous system
Unlike CB1 receptors, CB2 receptors are GPCRs located mainly on immune cells. The answer is C.
Nabilone and dronabinol are controlled substances with what type of scheduling by the Drug Enforcement Administration?
The answer is B; see text.
Which one of the cannabinoids is FDA-approved for use in patients with Lennox-Gastaut and Dravet syndromes?
Although the receptor and mechanism are unknown, cannabidiol has been shown to be effective in these seizure disorders. The answer is B.
Which one of the cannabinoids is well tolerated and does not result in reports of unwanted psychotropic effects?
Cannabidiol is effective in certain seizure disorders but does not act on CB1 or CB2 receptors. The answer is B.