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Chapter 60: Cannabinoid Drugs

Activation of the CB1 receptor on neurons results in

(A) Decreased calcium influx

(B) Increased protein kinase C (PKC)

(C) Decreased potassium efflux

(D) Increased protein kinase A (PKA)

(E) Increased cAMP

CB1 receptors are G1/0-coupled and reduce cAMP; they indirectly reduce calcium influx. The answer is A.

CB2 receptors are mainly located on

(A) Astrocytes of the CNS

(B) Endoplasmic reticulum

(C) Immune cells

(D) Neurons of the CNS

(E) Neurons of the peripheral nervous system

Unlike CB1 receptors, CB2 receptors are GPCRs located mainly on immune cells. The answer is C.

Nabilone and dronabinol are controlled substances with what type of scheduling by the Drug Enforcement Administration?

(A) Schedule I

(B) Schedule II

(C) Schedule III

(D) Schedule IV

(E) Schedule V

The answer is B; see text.

Which one of the cannabinoids is FDA-approved for use in patients with Lennox-Gastaut and Dravet syndromes?

(A) Anandamide

(B) Cannabidiol

(C) Dronabinol

(D) Medical marijuana

(E) Nabilone

Although the receptor and mechanism are unknown, cannabidiol has been shown to be effective in these seizure disorders. The answer is B.

Which one of the cannabinoids is well tolerated and does not result in reports of unwanted psychotropic effects?

(A) Anandamide

(B) Cannabidiol

(C) Dronabinol

(D) Medical marijuana

(E) Nabilone

Cannabidiol is effective in certain seizure disorders but does not act on CB1 or CB2 receptors. The answer is B.

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