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The purpose of this activity is for students to receive, process, and prepare an institutional order for a compounded sterile preparation (CSP).

Learning Objectives
  1. Ensure the dosing accuracy of an order for a CSP using tertiary drug information resources.

  2. Perform necessary calculations to confirm a safe, effective, and accurate final CSP.

  3. Utilize proper aseptic technique to prepare a CSP from a medication requiring reconstitution.

  4. Assign an appropriate beyond-use date for a CSP using relevant stability data and USP <797> specified sterility limits.

  5. Determine the compatibility of two intravenous CSPs at a common Y-site.

  6. Prepare a label for a CSP.

Foundational Knowledge Required

Pharmacy calculations, USP <797>, aseptic technique, IV product stability and compatibility, beyond-use dating of CSPs, use of drug information resources

Suggested Resources
  • USP-NF. <797> Pharmaceutical Compounding – Sterile Preparations.

  • Buchanan EC, Schneider PJ. Compounding Sterile Preparations. 3rd ed. Bethesda, MD: American Society of Health-Systems Pharmacists; 2009.

  • Handbook on Injectable Drugs. 20th ed. ASHP’s Guide to IV Compatibility and Stability. Bethesda, MD: American Society of Health-Systems Pharmacists; 2018.

  • Ansel HC, Stockton SJ. Pharmaceutical Calculations. 15th ed. New York, NY: Wolters Kluwer; 2017.

  • Lester Elder D. Sterile dosage forms and their preparation. In: A Practical Guide to Contemporary Pharmacy Practice and Compounding. 4th ed. New York, NY: Wolters Kluwer; 2018.

Assignment Instructions

Prior to lab, students should complete the Sterile Compounding Documentation to the best of their ability using appropriate tertiary drug information resources and the Package Insert for the medication. Students will prepare a Label for their CSP during the lab session. Students will need to check the dose of the ordered CSP for appropriateness, perform necessary calculations to prepare the CSP, assign an appropriate BUD, and determine Y-site compatibility.

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