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Harrison's® Principles of Internal Medicine, 21st edition

Copyright © 2022 by McGraw Hill LLC. Previous editions copyright © 2018, 2015 by McGraw-Hill Education; 2012, 2008, 2005, 2001, 1998, 1994, 1991, 1987, 1983, 1980, 1977, 1974, 1970, 1966, 1962, 1958 by The McGraw-Hill Companies, Inc. All rights reserved. Printed in the United States of America. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a data base or retrieval system, without the prior written permission of the publisher.

Harrison's® is a trademark of McGraw Hill.


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Two Volume Set ISBN 9781264268504; MHID 1264268505

Volume 1 ISBN 9781264268467; MHID 1264268467

Volume 2 ISBN 9781264268481; MHID 1264268483

eBook Two Volume Set ISBN 9781264268511; MHID 1264268513

Volume 1 eBook ISBN 9781264268474; MHID 1264268475

Volume 2 eBook ISBN 9781264268498; MHID 1264268491



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Chinese Short Form: (15e, 19e): McGraw-Hill Education (Asia), Singapore

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German: (17e, 18e, 19e, 20e): ABW Wissenschaftsverlagsgesellschaft GmbH, Berlin, Germany

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Portuguese: (17e, 18e): McGraw-Hill Interamericana Editores, SA de C.V., Mexico City, Mexico; (19e, 20e): AMGH Editora Ltda., Porto Alegre, Brazil

Romanian: (17e): Editura All, Bucharest, Romania; (19e): ALL Publishing House, Bucharest, Romania

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Spanish: (17e, 18e): McGraw-Hill Interamericana Editores, SA de C.V., Mexico City, Mexico; (19e, 20e): McGraw-Hill Mexico, Mexico City, Mexico

Turkish: (17e, 19e, 20e): Nobel Tip Kitabevleri, Ltd., Istanbul, Turkey

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This book was set in Palatino by KnowledgeWorks Global Ltd. The editors were James F. Shanahan and Kim J. Davis. The production manager was Jeffrey Herzich. Project management was provided by Revathi Viswanathan, KnowledgeWorks Global Ltd. The index was prepared by Susan Hunter. The text designer was Janice Bielawa; the cover design was by Anthony Landi. Figure 82-8 printed with permission from © Mount Sinai Health System.

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