On completion of the chapter, the reader will be able to:
- 1. Discuss the known etiologic factors of melanoma; including
both host factors and environmental factors.
- 2. Outline the pathogenesis of melanoma.
- 3. Identify the histologic subtypes of melanoma and describe
clinical features of each subtype.
- 4. Describe the clinical features of a pigmented lesion as
highlighted by the mnemonic ABCD; asymmetry, borders, colors, diameter.
- 5. Discuss strategies for early detection and prevention of
- 6. Describe the current staging of an individual diagnosed
- 7. Describe the controversy regarding the use of interferon
alfa as adjuvant therapy in high-risk individuals after surgical
- 8. Describe the common toxicities and appropriate management
strategies for interferon alfa in the treatment of individuals after
surgical resection of melanoma.
- 9. Describe the advantages and disadvantages of aldesleukin
therapy for the treatment of individuals with metastatic melanoma.
- 10. Describe the common toxicities and appropriate management
strategies for individuals receiving aldesleukin for the treatment
- 11. Formulate an appropriate treatment plan for a patient
receiving aldesleukin for metastatic melanoma.
- 12. Discuss the current role of chemotherapy, biochemotherapy,
and vaccines in the treatment of a patient with melanoma.
Melanoma is the sixth most common cancer in the United States. The incidence of melanoma steadily increased from the 1970s to the 1990s and has remained relatively stable since 2000. While nonmelanoma skin cancers (NMSCs) are the most common malignancies of the ...