Appendix E: Popular Drugs and Pharmacokinetic Parameters

Acetaminophen

88 ± 15

3 ± 1

0

350 ± 100

67 ± 8

2.0 ± 0.4

10–20 μg/mL

>300 μg/mL

Acyclovir

Alendrenate

15–30

0.59 (0.58–0.98)

75 ± 10

15 ± 4

330 ± 80

48 ± 13

2.4 ± 0.7 very long (related to bone turnover)

Alprazolam

88 ± 16

20

71 ± 3

0.74 ± 0.14 mL/min/kg

0.72 ± 0.12 L/Kg

12 ± 2

20–40 ng/mL

Alteplase (TPA)

—

Low

—

10 ± 4 mL/min/kg

0.1 ± 0.01 L/Kg

0.08 ± 0.04

Amikacin

98

4

91 ± 42

19 ± 4

2.3 ± 0.4

Amoxicillin

93 ± 10

86 ± 8

18

180 ± 28

15 ± 2

1.7 ± 0.3

Amphotericin B

2–5

>90

32 ± 14

53 ± 36

18 ± 7

Ampicillin

62 ± 17

82 ± 10

18 ± 2

270 ± 50

20 ± 5

1.3 ± 0.2

Aspirind

68 ± 3

1.4 ± 1.2

49

650 ± 80

11 ± 2

0.25 ± 0.3

See salicyclic acid

Atenolol

56 ± 30

94 ± 8

<5

170 ± 14

67 ± 11

6.1 ± 2.0

1 μg/mL

Atropine

50

57 ± 8

14–22

410 ± 250

120 ± 49

4.3 ± 1.7

Captopril

65

38 ± 11

30 ± 6

840 ± 100

57 ± 13

2.2 ± 0.5

50 ng/mL

Carbamazepined

>70

<1

74 ± 3

89 ± 37

98 ± 26

15 ± 5

6.5 ± 3 μg/mL

>9 μg/mL

Cephalexin

90 ± 9

91 ± 18

14 ± 3

300 ± 80

18 ± 2

0.90 ± 0.18

Cephalothin

52

71 ± 3

470 ± 120

18 ± 8

0.57 ± 0.32

Chloramphenicol

75–90

25 ± 15

53 ± 5

170 ± 14

66 ± 4

2.7 ± 0.8

Chlordiazepoxided

100

<1

96.5 ± 1.8

38 ± 34

21 ± 2

10 ± 3

>0.7 μg/mL

Chloroquined

89 ± 16

61 ± 4

61 ± 9

750 ± 120

13,000 ± 4600

8.9 ± 3.1 days

15–30 ng/mL

0.25 μg/mL

Chlorpropamide

>90

20 ± 18

96 ± 1

2.1 ± 0.4

6.8 ± 0.8

33 ± 6

Cimetidine

62 ± 6

62 ± 20

19

540 ± 130

70 ± 14

1.9 ± 0.3

0.8 μg/mL

Ciprofloxacin

60 ± 12

65 ± 12

40

420 ± 84

130 ± 28

4.1 ± 0.9

Clonidine

95

62 ± 11

20

210 ± 84

150 ± 30

12 ± 7

0.2–2 ng/mL

Cyclosporine

23.7

<1

93 ± 2

410 ± 70

85 ± 15

5.6 ± 2

100–400 ng/mL

>400 ng/mL

Diazepamd

100

<1

98.7 ± 0.2

27 ± 4