Sections View Full Chapter Figures Tables Videos Full Chapter Figures Tables Videos Supplementary Content ++Table Graphic Jump LocationTable C-1 Adult Intrathecal Analgesic Injections*View Table||Download (.pdf)Table C-1 Adult Intrathecal Analgesic Injections*ClassMedicationUsual DoseOnsetDurationConcentrationSide EffectsOpioid AnalgesicsFentanyl5–25mcg/dose5–10min1–4h0.05mg/mL PFSedation, N/V, urinary retention, respiratory depression, constipationHydromorphone50–100mcg/dose††10mg/mL PFSedation, N/V, pruritus, urinary retention, respiratory depression, constipationMorphine0.2–1mg/dose (APS recommends 0.1–0.3mg/dose)45–75min18–24h0.5, 1, 10, 25mg/mL PFSedation, N/V, pruritus, urinary retention, respiratory depression, constipationSedativesMidazolam1–2mg/dose5–10min2–4h1, 5mg/mL PF (diluted to max conc 1mg/mL)Sedation, motor weakness, respiratory depressionNonopioid AdjuvantsBaclofen25–75mcg/dose30–60min4–8h0.05, 0.5, 2mg/mL PFSedation, cognitive impairment, weakness, hypotension, constipation, urinary retentionClonidine25–75mcg30–60min6–8h100, 500mcg/mL PFOrthostatic hypotension, bradycardia, sedation++Table Graphic Jump LocationTable C-2 Adult Intrathecal Antimicrobial Injections*View Table||Download (.pdf)Table C-2 Adult Intrathecal Antimicrobial Injections*MedicationUsual DoseConcentrationRouteSide EffectsAmikacin5–20mg/d4mg/mL PFNSIT‡Minor hearing lossAmphotericin B0.01–0.5mg/d0.1mg/mL D5WIT/IVT‡Tinnitus, fever, chills, parkinsonismGentamicin4–8mg/d2mg/mL PFNSIT/IVT‡Transient hearing loss, seizures, aseptic meningitisTobramycin4–8mg/d2mg/mL PFNSIT/IVT‡Transient hearing loss, seizures, aseptic meningitisVancomycin5–20mg/d5mg/mL PFNSIT/IVT‡Sensorineural hearing lossAPS, American Pain Society; IT, intrathecal; IVT, intraventricular; N/V, nausea & vomiting; PFNS, preservative-free normal saline.*Information provided as a medical resource but not intended to replace physician's judgment.†Information not available.‡Not FDA approved by this route.References: Rathmell JP, Lair TR, Nauman B. The role of intrathecal drugs in the treatment of acute pain. Anesth Analg 2005;101: S30; Tunkel AR, et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 2004;39:1267; Ziai W, Lewin III JJ. Improving the role of intraventricular antimicrobial agents in the management of meningitis. Curr Opin Neurol 22:277. Your MyAccess profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'. Please click ‘Continue’ to continue the affiliation switch, otherwise click ‘Cancel’ to cancel signing in. Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Username Error: Please enter User Name Password Error: Please enter Password Forgot Username? Forgot Password? Sign in via OpenAthens Sign in via Shibboleth