Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ Abbreviations ++Table Graphic Jump Location|Download (.pdf)|PrintANVAnticipatory nausea and vomitingCINVChemotherapy-induced nausea and vomitingCOX-2Cyclooxygenase-2GERDGastroesophageal reflux disease5-HT35-Hydroxytryptamine-3H2RAHistamine 2 receptor antagonistMALTMucosa-associated lymphoid tissueNK-1Neurokinin 1NSAIDNonsteroidal anti-inflammatory drugPONVPostoperative nausea and vomitingPPIProton pump inhibitorPUDPeptic ulcer diseaseRINVRadiation-induced nausea and vomiting++Table Graphic Jump LocationTable 5.1.1 Drugs for Treatment of Nausea and VomitingView Table||Download (.pdf)Table 5.1.1 Drugs for Treatment of Nausea and VomitingDrugTypical DosingDosage FormsAntihistaminic/Anticholinergic AgentsaCyclizine (Marezine)50 mg before travel; may repeat in 4–6 h PRNTabDimenhydrinate (Dramamine)50–100 mg Q 4–6 h PRNTab, chew tab, capDiphenhydramine (Benadryl)25–50 mg Q 4–6 h PRNTab, cap, liquid10–50 mg Q 2–4 h PRNIM, IVHydroxyzine (Vistaril, Atarax)25–100 mg Q 4–6 h PRNIM (unlabeled use)Meclizine (Antivert)12.5–25 mg 1 h before travel; repeat Q 12–24 h PRNTab, chew tabScopolamine (Transderm Scop)1.5 mg Q 72 hTransdermal patchTrimethobenzamide (Tigan)300 mg TID-QIDCapBenzodiazepinesbAlprazolam (Xanax)0.5–2 mg TIDTabLorazepam (Ativan)0.5–1 mg TIDTab, IVDopamine-2 Receptor AntagonistsChlorpromazine (Thorazine)10–25 mg Q 4–6 h PRNTab, liquid25–50 mg Q 4–6 h PRNIM, IVDroperidol (Inapsine)2.5 mg; additional 1.25 mg may be givenIM, IVHaloperidol (Haldol)1–5 mg Q 12 h PRNTab, liquid, IM, IVMetoclopramide (Reglan)10 mg QID (before meals and at bedtime)Tab, IV20–40 mg TID-QIDTab, IVProchlorperazine (Compazine)5–10 mg 3–4 QD PRNTab, liquid5–10 mg Q 3–4 h PRNIM2.5–10 mg Q 3–4 h PRNIV25 mg BID PRNSuppPromethazine (Phenergan)12.5–25 mg Q 4–6 h PRNTab, liquid, supp, IMc5-HT3 Receptor AntagonistsOndansetron (Zofran)4–8 mg BID-TIDTab, ODT, IVaBest used for vestibular nausea and vomiting.bWeak antiemetics, useful as adjuncts or for anxiety-related nausea and vomiting.cAvoid giving IV due to risk of severe extravasation injury.++Table Graphic Jump LocationTable 5.1.2 Drugs and Dosing for Prophylaxis of CINV and RINVView Table||Download (.pdf)Table 5.1.2 Drugs and Dosing for Prophylaxis of CINV and RINVDrugIndicationDosingDosage Forms5-HT3 Receptor AntagonistsDolasetron (Anzemet)CINV100 mg before chemoTabDelayed CINV100 mg QDTabGranisetron (Kytril)CINV, RINV2 mg before chemo/radiationTabDelayed CINV1–2 mg QDTabCINV1 mg before chemoIVCINV34.3 mg applied 24 h prior to chemoTransdermal patchOndansetron (Zofran)CINV16-24 mg before chemoTab, ODTCINV8–12 mg before chemo/radiationIVRINV8 mg BIDTab, ODTDelayed CINV8 mg QD-BIDTab, ODTPalonosetron (Aloxi)CINV0.25 mg before chemoIVCINV0.5 mg before chemoTabNK-1 Receptor AntagonistAprepitant (Emend)CINV125 mg before chemoCapDelayed ... Your Access profile is currently affiliated with [InstitutionA] and is in the process of switching affiliations to [InstitutionB]. Please select how you would like to proceed. Keep the current affiliation with [InstitutionA] and continue with the Access profile sign in process Switch affiliation to [InstitutionB] and continue with the Access profile sign in process Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Error: Incorrect UserName or Password Username Error: Please enter User Name Password Error: Please enter Password Sign in Forgot Password? Forgot Username? Download the Access App: iOS | Android Sign in via OpenAthens Sign in via Shibboleth You already have access! Please proceed to your institution's subscription. Create a free profile for additional features.