Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ Abbreviations ++Table Graphic Jump Location|Download (.pdf)|PrintAAdultAPAntipsychoticBZDBenzodiazepineBZRABenzodiazepine receptor agonistCCapsuleCPAPContinuous positive airway pressureDxDiagnosisEElderlyECGElectrocardiogramECTElectroconvulsive therapyHxHistoryMAOIMonoamine oxidase inhibitorQIDS-SRQuick Inventory of Depressive Symptomatology—Self-ReportPHQ9Patient health questionnaireRLSRestless legs syndromeSSolutionSNRISerotonin–norepinephrine reuptake inhibitorSSRISelective serotonin reuptake inhibitorTTabletTCATricyclic antidepressant++Figure 9.1.1 Assessment and Management of Depression AlgorithmGraphic Jump LocationView Full Size||Download Slide (.ppt)Source: American Psychiatric Association. Practice Guideline for the Treatment of Patients with Major Depressive Disorder. 3rd ed. Arlington, VA: American Psychiatric Association; 2010.++Table Graphic Jump LocationTable 9.1.2 Antidepressant Drug DosingView Table||Download (.pdf)Table 9.1.2 Antidepressant Drug DosingMedicationDosage FormsUsual Dosing RangeMonitoringSSRIsCitalopramTablet, oral solution20–40 mg/dayMonitor ECG. Mg+ and K+ due to QTc prolongationEscitalopramTablet, oral solution10–20 mg/dayFluoxetineTablet, capsule, oral solution20–80 mg/dayAvoid use in elderly and those with hepatic impairment (long t1/2)ParoxetineTablet, controlled release tablet, oral suspension10–60 mg/dayAvoid abrupt discontinuation due to withdrawal syndromeSertralineTablet, oral solution25–200 mg/dayDual Reuptake InhibitorsBupropionImmediate release tablet300–450 mg/day, dividedContraindicated in seizure disorder or eating disordersSustained release tablet150–400 mg/day, dividedExtended release tablet150–300 mg/dayDuloxetineDelayed-release capsule20–60 mg/dayMay cause urinary hesitationAvoid in hepatic impairment, chronic alcohol abuse or CrCl <30 mL/minVenlafaxineTablet, extended release capsule, sustained release tablet75–300 mg/dayMonitor blood pressureAvoid abrupt discontinuation due to withdrawal syndromeMay see a “ghost tablet” with sustained releaseDesvenlafaxineTablet, oral disintegrating tablet50–400 mg/dayAvoid abrupt discontinuation due to withdrawal syndromeTCAsAmitriptylineTablet10–300 mg/dayMay cause blue-green urineDesipramineTablet10–300 mg/dayMay cause blue-green urineImipramineTablet, capsule10–300 mg/dayNortriptylineCapsule, oral solution30–150 mg/dayMAOIsPhenelzineTablet60–90 mg/day, dividedRequired medication and dietary restrictionsSelegilineTransdermal patch6–12 mg/dayDietary restrictions for 9 and 12 mg patchesTranylcypromineTablet10–60 mg/dayMore rapid onset than tricyclicsRequired medication and dietary restrictionsIsocarboxazidTablet20–60 mg/day, dividedRequired medication and dietary restrictionsNovel Mechanism AgentsMirtazapineTablet, oral disintegrating tablet15–45 mg/dayCauses significant sedationMay increase triglyceridesMonitor weightNefazodoneTablet300–600 mg/dayMonitor liver function, signs of hepatic failureTrazodoneTablet150–600 mg/dayGive at bedtimeCauses sedationMay cause priapismVilazodoneTablet20–40 mg/dayMust take with food for adequate absorptionReprinted with permission from Mascarenas CA. Major depressive disorder. In: Richardson MM, Chessman KH, Chant C, Cheng JWM, Hemstreet BA, Hume AL, et al., eds. Pharmacotherapy Assessment Program. 7th ed. Neurology and Psychiatry. Lenexa, KS: American College of Clinical Pharmacy;2012:7–26.++Table Graphic Jump LocationTable 9.1.3 Depression Augmentation MedicationsView Table||Download (.pdf)Table 9.1.3 Depression Augmentation ... Your Access profile is currently affiliated with [InstitutionA] and is in the process of switching affiliations to [InstitutionB]. Please select how you would like to proceed. Keep the current affiliation with [InstitutionA] and continue with the Access profile sign in process Switch affiliation to [InstitutionB] and continue with the Access profile sign in process Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Error: Incorrect UserName or Password Username Error: Please enter User Name Password Error: Please enter Password Sign in Forgot Password? Forgot Username? Download the Access App: iOS | Android Sign in via OpenAthens Sign in via Shibboleth You already have access! Please proceed to your institution's subscription. Create a free profile for additional features.