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Source: Lee M. Erectile
Dysfunction. In: DiPiro, JT, Talbert RL, Yee GC, Matzke GR, Wells
BG, Posey LM. Pharmacotherapy: A Pathophysiologic Approach. 8th edition. http://accesspharmacy.com/content.aspx?aid=7994506.
Accessed July 10, 2012.
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- Failure to achieve penile erection suitable for sexual
intercourse
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- Abnormality in system necessary for penile erection
- Organic erectile dysfunction (ED): Vascular, nervous,
or hormonal systems—80% of patients
- Psychogenic ED: Psychological etiology
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- Interconnected sinuses in two corpora cavernosa in penis
fill with blood to produce erection.
- Acetylcholine works with other neurotransmitters (i.e., cyclic
guanylate monophosphate, cyclic adenosine monophosphate, and vasoactive
intestinal polypeptide) to produce penile arterial vasodilation
and ultimately erection.
- Organic ED associated with diseases that:
- Compromise
vascular flow to corpora cavernosum (e.g., peripheral vascular disease,
arteriosclerosis, and essential hypertension)
- Impair nerve conduction to brain (e.g., spinal cord injury
and stroke)
- Impair peripheral nerve conduction (e.g., diabetes mellitus)
- Secondary ED associated with hypogonadism.
- Psychogenic ED associated with:
- Malaise
- Reactive depression
- Performance anxiety
- Sedation
- Alzheimer’s disease
- Hypothyroidism
- Mental disorders
- Social habits (e.g., cigarette smoking and excessive ethanol
intake) and medications (Table 1)
can also cause ED
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- Incidence increases as men age
- Often associated with concurrent medical conditions
- Diabetes mellitus
- Hypertension—medications may contribute to ED
- Arteriosclerosis
- Hyperlipidemia
- Psychiatric disorders
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