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Kramer Questionnaire

Kramer MS, Leventhal JM, Hutchinson TA, Feinstein AR. An algorithm for the operational assessment of adverse drug reaction: I. background, descriptions, and instructions for use. JAMA. 1979; 242(7):623-32.

Figure 1.

Axis I. Previous general experience with drug.

Figure 2.

Axis II. Alternative etiologic candidates. For explanation of abbreviations, see Axis I.

Figure 3.

Axis III. Timing of events. For explanation of abbreviations, see Axis I.

Figure 4.

Axis IV. Drug levels and evidence of overdose. For explanation of abbreviations, see Axis I.

Figure 5A.

Axis V-A. Dechallenge: difficult assessments. For explanation of abbreviations, see Axis I.

Figure 5B.

Axis V-B. Dechallenge: absence of dechallenge. For explanation of abbreviation, see Axis I.

Figure 5C.

Axis V-C. Dechallenge: improvement after dechallenge. For explanation of abbreviation, see Axis I.

Figure 6.

Axis VI. Rechallenge. For explanation of abbreviation, see Axis I.

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