Endnotes

Overington  JP, Al-Lazikani  B, Hopkins  AL: How many drug targets are there? Nat Rev Drug Discov 5(12):993–6, 2006.
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von Zastrow  M, von Zastrow  M: Chapter 2. Drug receptors & pharmacodynamics, in Katzung  BG, Masters  SB, Trevor  AJ (eds). Basic & Clinical Pharmacology, 12th ed. New York: McGraw-Hill, 2012. www.accesspharmacy.com.lp.hscl.ufl.edu/content.aspx?aID=55820126. Accessed August 1 , 2013.

Charmot, D: Non-systemic drugs: A critical review. Curr Pharm Des 18(10):1434–45, 2012.
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Shargel  L, Wu-Pong  S, Yu  AB: Chapter 14. Biopharmaceutic considerations in drug product design and in vitro drug product performance, in Shargel  L, Wu-Pong  S, AB  Yu (eds). Applied Biopharmaceutics & Pharmacokinetics, 6th ed. New York: McGraw-Hill, 2012. www.accesspharmacy.com.lp.hscl.ufl.edu/content.aspx?aID=56604846. Accessed August 1 , 2013.

Giacomini  KM, Sugiyama  Y: Chapter 5. Membrane transporters and drug response, in Brunton  LL, Chabner  BA, Knollmann  BC (eds). Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th ed. New York: McGraw-Hill, 2011. www.accesspharmacy.com.lp.hscl.ufl.edu/content.aspx?aID=16658945. Accessed August 1 , 2013.

Buxton  IL, Benet  LZ: Chapter 2. Pharmacokinetics: The dynamics of drug absorption, distribution, metabolism, and elimination, in Brunton  LL, Chabner  BA, Knollmann  BC (eds). Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th ed. New York: McGraw-Hill, 2011. www.accesspharmacy.com.lp.hscl.ufl.edu/content.aspx?aID=16658120. Accessed August 1 , 2013.

Zamek-Gliszczynski  MJ, Hoffmaster  KA, Nezasa  K, Tallman  MN, Brouwer  KL: Integration of hepatic drug transporters and phase II metabolizing enzymes: Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites. Eur J Pharm Sci 27(5):447–86, 2006. Epub February 10 , 2006.
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Shargel  L, Wu-Pong  S, Yu  AB: Chapter 10. Physiologic drug distribution and protein binding, in Shargel  L, Wu-Pong  S, AB  Yu (eds). Applied Biopharmaceutics & Pharmacokinetics, 6th ed. New York: McGraw-Hill, 2012. www.accesspharmacy.com.lp.hscl.ufl.edu/content.aspx?aID=56603200. Accessed August 1 , 2013.

Luc EC De  Baerdemaeker, LEC, Mortier, EP, Struys  MMRF: Pharmacokinetics in obese patients. Contin Educ Anaesth Crit Care Pain 4(5):152–5, 2004.
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Prouillac  C, Lecoeur  S: The role of the placenta in fetal exposure to xenobiotics: Importance of membrane transporters and human models for transfer studies. Drug Metab Dispos 38(10):1623–35, 2010.
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Correia  MA: Chapter 4. Drug biotransformation, in Katzung  BG, Masters  SB, Trevor  AJ (eds). Basic & Clinical Pharmacology, 12th ed. New York: McGraw-Hill, 2012. www.accesspharmacy.com.lp.hscl.ufl.edu/content.aspx?aID=55820515. Accessed August 1 , 2013.

Gonzalez  FJ, Coughtrie  M, Tukey  RH: Chapter 6. Drug metabolism, in LL Brunton, Chabner  BA, Knollmann  BC (eds). Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th ed. New York: McGraw-Hill, 2011. www.accesspharmacy.com.lp.hscl.ufl.edu/content.aspx?aID=16659426. Accessed August 1 , 2013.

Shargel  L, Wu-Pong  S, Yu  AB: Chapter 11. Drug elimination and hepatic clearance, in ...