TY - CHAP M1 - Book, Section TI - Nonlinear Pharmacokinetics A1 - Yu, Andrew B.C. A1 - Shargel, Leon A2 - Shargel, Leon A2 - Yu, Andrew B.C. PY - 2016 T2 - Applied Biopharmaceutics & Pharmacokinetics, 7e AB - Describe the differences between linear pharmacokinetics and nonlinear pharmacokinetics.Illustrate nonlinear pharmaco­kinetics with drug disposition examples.Discuss some potential risks in dosing drugs that follow nonlinear kinetics.Explain how to detect nonlinear kinetics using AUC-versus-doses plots.Apply the appropriate equation and graphical methods, to calculate the Vmax and KM parameters after multiple dosing in a patient.Describe the use of the Michaelis–Menten equation to simulate the elimination of a drug by a saturable enzymatic process.Estimate the dose for a nonlinear drug such as phenytoin in multiple-dose regimens.Describe chronopharmaco­kinetics, time-dependent pharmacokinetics, and its influence on drug disposition.Describe how transporters may cause uneven drug distribution at cellular level; and understand that capacity-limited or concentration-dependent kinetics may occur at the local level within body organs. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1117898518 ER -